Polycystic ovary syndrome: potential targets in blood leukocytes

CARDOZO, MARÍA ALEJANDRA; ACOSTA, MARÍA V; BRACHO, GISELA S; ANDREOLI, MARÍA FLORENCIA; BOSQUIAZZO, VERÓNICA LIS

Mar del Plata

Congreso; LXVIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2023

Sociedad Argentina de Investigación Clínica (SAIC)

Polycystic ovary syndrome (PCOS) is the most common hormonal disorder in reproductive‐aged women. In these patients, obesity, insulin and leptin resistance and inflammation are prevalent findings and are associated with comorbidities that include development of conditions like type 2 diabetes mellitus, hypertension, and metabolic syndrome. The aim of this study was to evaluate the expression of different molecules, leptin receptor (LEPR), insulin receptor (INSR), insulin receptor substrate 1 and 2 (IRS1, IRS2) and suppressor of cytokine signaling 3 (SOCS3) in blood leukocytes as potential biomarkers of metabolic and inflammatory status in PCOS women. Women in reproductive age (20 to 40 years) with and without PCOS were recruited and these were matched for body mass index (range 20.7-39.3). The mRNA expression of the mentioned molecules was evaluated by real-time RT-PCR. Similar expression of LEPR, INSR, IRS1 and IRS2 were observed between women with and without PCOS (p>0.05). However, SOCS3 increased in PCOS women (p