LIRAGLUTIDE REGULATES SERTOLI CELL ENERGETIC METABOLISM

DASSO, M.E.; CENTOLA, C.L.; GALARDO, M.N.; MERONI, S.B.; RIERA, M.F.

Valdivia

Congreso; Congreso 2023; 2023

Sociedad Chilena de Reproducción y Desarrollo

Sertoli cells (SC) provide the nutritional support for developing germ cells. They metabolize glucose to lactate, which is delivered to germ cells to be used as energy substrate. Besides, SC can use fatty acids (FA) as source of energy and can store them as triacylglycerols (TAG) within lipid droplets (LD). The LD content is important to maintain energetic reserve in SC. Obesity prevalence has risen dramatically and liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has emerged as a useful drug for treatment of obesity. It has been observed that liraglutide regulates cell metabolism in different cell types. Considering that SC energetic metabolism may be relevant to seminiferous tubule physiology, the aim of this work was to assess if liraglutide regulates lactate production and LD storage in SC.