Overexpression of the IL-33 alarmin in the small intestinal mucosa of celiac disease patients

FEDERICO PEREZ; DAVID DIAZ JIMENEZ; MARJORIE DE LA FUENTE; GLAUBEN LANDSKRON; CAROLINA N. RUERA; FERNANDO CHIRDO

Valencia

Encuentro; 30th Meeting of the European Prolamin Working Group of Prolamin Analysis and Toxicity; 2016

Working Group of Prolamin Analysis and Toxicity

.In this study, we found higher levels of IL-33 and sST2 in serum of untreated CD patients compared with healthy controls, together with an increase in the number of IL-33+ and ST2+ cells in duodenal lamina propria of untreated CD patients. Since IL-33 is mainly located in the nucleus of different cells, upregulation of IL-33 expression points to its role as alarm signal.Though the test used to evaluate serum IL-33 levels does not discriminate active and inactive form, it is likely that part of the circulating IL-33, released from the intestinal mucosa, may reach distant tissues initiating a tissue damage process. IL-33 together with other cytokines, such as IFN- and IL-15 may also be part of the inflammatory mediators which link CD to other inflammatory/autoimmune diseases such as type I diabetes and rheumatoid arthritis.