Preliminary Study on the Optimization of Chitosan Nanoparticles Processing Using the Electrospraying Technique for Embelin Encapsulation

AGUSTÍN MARTINEZ CEBADA; ANA L. SUARES SEGURA; BEATRIZ LIMA; ALEJANDRO TAPIA; GUSTAVO A. ABRAHAM; PABLO R. CORTEZ TORNELLO

Mar del Plata, Buenos Aires

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials; 2023

INTEMA (UNMDP-CONICET)/LABOATEM (UNR-CONICET)

The development of polymeric nanoparticles has become the subject of intenseresearch in the field of Health by Bioengineering and Materials Engineering, as it allows the creation of highlyfunctional systems with applications in disease diagnosis, prevention, and treatment. These nanoparticles havefound significant use as biomaterials for the release of therapeutic agents. Chitosan is a natural polymerabundant in nature, holds great importance in the biomedical field due to its excellent properties ofbiodegradability, biocompatibility, mucoadhesion, films-forming capability, hemostatic andabsorption-promoting properties. Moreover, it exhibits antimicrobial, anticholesterolemic, and antioxidantactivities. The objective of this work is to optimise the processing conditions for obtaining Chitosannanoparticles using the monoaxial electrospraying technique, as well as to encapsulate of embelin using coaxialelectrospraying.