LEPTIN EFFECTS ON THE EXPRESSION OF RAC3 COACTIVATOR

IARA CASTELLANOS; FRANCISCO DAMIÁN ROSA; MARÍA CECILIA LIRA; JULIANA LOURDES BERNACCHIA; MARÍA FLORENCIA QUINTANILLA; ALEJANDRA GRACIELA PALMA; MÓNICA ALEJANDRA COSTAS; MARÍA FERNANDA RUBIO

Congreso; SAIC (Sociedad Argentina de Investigación Clínica); 2023

Adipocytes account for the largest proportion among the cells that comprise breast tissue. Although they are considered to be a critical cell type in the tumor microenvironment of breast cancer, it is still unclear the molecular mechanisms that control their behavior in this context. We have demonstrated that the expression of the coacti- vator RAC3 decreases during adipogenesis and was increased in adipose tissue adjacent to breast tumors. Therefore, the aim of this work was to study if leptin was able to modulate RAC3 expression. From the systematic review of 20 papers, we confirmed the as- sociation between serum leptin levels and the presence of breast cancer in postmenopausal women (test for overall effect Z=11.98, p