DIRECT ACTION OF INTESTINAL MICROORGANISMS IN COLORECTAL CANCER CELL LINE

BERNACCHIA JULIANA LOURDES; ALEJANDRA GRACIELA PALMA; MARÍA CECILIA LIRA; FRANCISCO DAMIÁN ROSA; ADRIANA DE PAULIS; OSCAR LAUDANNO; MICAELA LLEYDA; SUSANA NOWICKI; MÓNICA VÁZQUEZ-LEVIN; MARÍA FERNANDA RUBIO; MÓNICA ALEJANDRA COSTAS

Congreso; SAIC (Sociedad Argentina de Investigación Clínica); 2022

Numerous evidence demonstrate the importance of the microbi- ome mainly due to its immunological action, in the development of multiple diseases, such as colorectal cancer (CRC). In agreement with previous works, bacteria such as Escherichia coli (E.coli) and Bacteroides fragilis, among others, have high prevalence in CRC patients compared to the normal population. In this work we inves- tigate the possible pathways and signaling that may contribute to CRC development that could be affected by direct action of bacte- ria over colorectal cancer cells, in the absence of additional signals from the immune system. Therefore, we first determined the total amount of genes that were up or down regulated (log FC >1 or 4, thus, strongly involved in CRC.We conclude, there are signals and pathways independent of the immune system that could be induced directly by bacteria in the ep- ithelial colorectal cells, contributing to CRC.