Distribution of APP in endo-lysosomal system induced by Aβ is modulated by Gβγ signaling

MAGDALENA ANTONINO; PAULA MARMO; ROMINA ALMIRON; ALFREDO LORENZO; ELENA ANAHI BIGNANTE

Amsterdam

Congreso; Alzheimer's Association International Conference® (AAIC®); 2023

Alzheimer's Association

Alzheimer ́s disease is characterized by the deposition of aggregated species of amyloidbeta (Aβ) in the brain, which leads to progressive cognitive deficits and dementia. We recently foundthat Aβ assemblies, oligomers and fibrils, increase APP and BACE1 interaction in recycling endosomes and accumulation of intracellular Aβ42 in human neurons derived from iPSCs by a mechanism dependent of APP/Go/Gβγ signaling (Antonino et al 2022, DOI: 10.3389/fcell.2022.852738). Now, we are interested on deepen in the APP trafficking in the endo-lysosomal pathway in order to understand the mechanism underlying such effect.