MG ZX10 FOR PERIPHERAL NERVE REGENERATION: COMPARATIVE CORROSION STUDIES UNDER SIMULATED BIOLOGICAL CONDITIONS

LUCIANA MALVESTITI; FLORENCIA TANO DE LA HOZ; VANINA USACH; PATRICIA SETTON; MARIA ROSA KATUNAR; SILVIA CERÉ

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials; 2023

Peripheral neuropathies are neurodegenerative diseases caused by dysfunction of one or more peripheral nerves. Magnesium (Mg)-based alloys emerge as potential biomaterials for the construction of nerve guide conduits. The primary constraint associated with this element is its high corrosion rate in the physiological environment. Moreover, the sterilization process and its impact are frequently overlooked in material research studies, despite its crucial nature. Sterilized and unsterilized (control) Mg ZX10 alloy were studied. Its degradation was evaluated in SBF (simulated physiological solution) and in DMEM (Dulbecco's modified Eagle's medium) high glucose with 10% fetal bovine serum (FCS) and its cytocompatibility was analyzed.