PTHrP PROMOTES AN AGGRESSIVE BEHAVIOR OF CRC CELLS THROUGH ITS ACTION ON TUMOR AND STROMAL CELLS.

NOVOA DÍAZ BELEN; CARRIERE PEDRO MATÍAS; BIRKENSTOCK CINTIA; GONZALO PICARDI; GOMEZ LUIS; GIGOLA, GRACIELA; ZWENGER ARIEL; CALVO, NATALIA; GENTILI, CLAUDIA

Mar del Plata

Congreso; REUNIÓN CONJUNTA SAIC SAB AAFE AACYTAL 2023; 2023

Sociedad Argentina de Investigación Clínica

In tumor microenvironment (TME) several cells and molecules interact, favoring tumor development. Previously we found that parathyroid hormone-related peptide (PTHrP), a cytokine from TME, promotes an aggressive phenotype in HCT116 cells from colorectal cancer (CRC) and that conditioned medium (CM) from PTHrP-treated HMEC-1 endothelial stromal cells induces epithelial to mesenchymal transition (EMT) in CRC cells. This work aims to further study PTHrP effects on CRC and its TME. HCT116 cells were treated with the CM. Western blot (WB) analysis showed that CM modulates the expression and activation of Met, a receptor related to CRC (p