MAGNESIUM ALLOY (AZ91) FUNCTIONALIZATION WITH SILICA-GENTAMICIN NANOPARTICLES FOR BIODEGRADABLE IMPLANTS

MELINA HANKOVITS; JULIETA MERLO; MARÍA K. HERRERA SEITZ; JOSEFINA BALLARRE; SILVIA CERÉ

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials (COLAOB); 2023

INTEMA

Biodegradable metals, such as magnesium-based alloys, are extensively studied as temporary implants. These materials must be biocompatible and minimize the release of potentially toxic ions into tissues. Also, as in any surgical procedure, there is a risk of local infection. In order to improve medical treatments, there is a need to locally release antibiotics to avoid systemic doses. Silica-based nanomaterials, usually in the form of spherical nanoparticles, exhibit potential as drug carriers and delivery systems. The objective of this study is to develop and characterize a silica-gentamicin (Si-Ge) system on a pre-treated surface of a magnesium-based AZ91 alloy.