INVESTIGADORES
FERNANDEZ Barbara
congresos y reuniones científicas
Título:
MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS GENOTYPES INFLUENCE CELLULAR IMMUNE RESPONSE OF EXPERIMENTALLY INFECTED CALVES
Autor/es:
COLAVECCHIA, SB.; FERNÁNDEZ, B.; BENAVIDES, G.; STEMPLER, A; FORTUNY, M. L.; REGNER, P.; PAOLICCHI, F.A.; MUNDO, S. L.
Lugar:
Milan
Reunión:
Simposio; 10th International Veterinary Immunology Symposium; 2013
Institución organizadora:
International Veterinary Immunology Symposium
Resumen:
Paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (Map), is a chronic granulomatous enteritis affecting ruminants. The aim of the study was to evaluate cellular immune response induced by two bovine genotypes of Map isolated in Argentina. Holstein calves (6-8 weeks old) were experimentally infected using an oral dose (246 mg of total wet weight) of Map genotype A (MA, n=3) or C (MC, n=2) and mock infected (MI, n=2). Calves were evaluated during 150 days postinfection. Map, avian purified protein derivative (PPDa), bovine purified protein derivative (PPDb) and lipoarabinomannan (LAM) specific proliferation, IFN-γ production and CD4, CD8, WC1 and CD25+ cell subpopulations were determined. Intradermal comparative test (ICT) was measured at day 160. From day 30 Map, PPDa and PPDb stimulation index (SI) were greater in infected groups than in MI (p
