Modifications in the expression of S100ß and serotonin in trigeminal subnucleus after pulpar molar injury

CANZOBRE, M.C.; FOSSER, N.S.; RIOS, H.

Pinamar, Pcia. de Buenos Aires

Congreso; XX Reunión anual de la Sociedad Argentina de Neuroquímica; 2005

Visual experience is a main issue in visual system maturation. This process includes a refinement of retinal synaptic circuitry mediated by a complex interplay between genetic and epigenetic factors.             There are increased evidences that light or dark rearing play a role in the morphological and functional maturation of retinal circuits. We have previously described 5HT-amacrine cells of chick retina during pre and postnatal development. In addition, we have showed the darkness induced neuroplastic changes over those amacrine cells (Fosser et al., 2005).  Red light rearing produces a lack of pruning of 5HT amacrine dendrites.  These changes could be necessary to decrease retinal threshold, and thus increase visual sensitivity.  Besides, red light rearing produces a lack of pruning of 5HT amacrine dendrites.  In this work we extend our immunocytochemical study on the serotoninergic system of chick retina through the analysis of the expression pattern of three serotoninergic receptors (5HTR1A, 2C and 3) during visual hypostimulation conditions.             Our preliminary data suggests that an expression pattern of serotoninergic receptors are conditioned by visual-activity.  Besides, light affects not only the pruning of the serotonin amacrine-cells arborizations, but also spatial distribution of serotonin receptors.  (UBACyT O007).