Design of porous orally disintegrating tablets by direct compression and sublimation

JUAN, C.; GALLO, L. C.; GONZALEZ VIDAL, N. L.

Córdoba (formato virtual)

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas - RICiFa 2020+1; 2021

Universidad Nacional de Córdoba

Orally disintegrating tablets (ODTs) offer many advantages over conventional tablets, specially forpediatric population. Direct compression is a straightforward method of producing ODTs. However,the relatively low porosity of the tablets prolongs the disintegration time. In this sense, the aim of thiswork was to design ODTs by direct compression including a sublimating agent, in order to obtainhighly porous tablets.Tablets consisting of a model drug (ivermectin), sublimating agent (camphor), diluent,superdisintegrant, lubricant, glidant and a sweeting agent were produced in an excentric tablet press.Tablets were kept at 60 °C for 72 h in an oven, to ensure complete sublimation, verified by weightloss. Tablet hardness, friability and disintegration time were evaluated, and compared with controltablets (without camphor). Results showed that porous tablets disintegrated approximately 42% fasterthan control samples. Hardness results were 2.8 Kp and 5.1 Kp for porous and control tablets,respectively. However, friability for porous tablets (1.89%) exceeded the acceptance criteria, butcontrol tablets did not (0.42%).In conclusion, these preliminary results are very promising, since ODTs with satisfactorydisintegration times were produced. Futher investigations should be carried out in order to improvefriability and optimize the formulations.