IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Ceftriaxone prevents the impairment of glutamate homeostasis in the nucleus accumbens core and behavioral cross-sensitization to cocaine following chronic restraint stress
Autor/es:
GUZMAN, ANDREA S.; VEDELAGO, GEORGINA; CANCELA, LILIANA M.; AVALOS, MARIA P.; MONGI BRAGATO B; SANCHEZ MARIANELA ADELA; CALFA, D. GASTON; BOLLATI, FLAVIA A
Lugar:
Buenos Aires
Reunión:
Congreso; Ceftriaxone prevents the impairment of glutamate homeostasis in the nucleus accumbens core and behavioral cross-sensitization to cocaine following chronic restraint stress; 2022
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencia
Resumen:
Though the facilitating influence of stress on drug abuse is well documented, the mechanisms underlying this interaction have yet to be fully elucidated. The present study explores the glutamatergic mechanisms in the nucleus accumbens core (NAcore) underpinning the sensitized response to the psychomotor-stimulating effects of cocaine following chronic restraint stress (CRS). Adult male Wistar rats were restrained for 2 hours/day for seven days (day 1-7). From day 17 until completing the experimental protocol (day 17-21), animals received a 5-day systemic treatment with ceftriaxone, a known enhancer of the glutamate transporter GLT-1, or vehicle. On day 21, all animals were randomly assigned to behavioral, microscopic, biochemical or neurochemical tests. Our results demonstrated that ceftriaxone prevents the increase of basal extracellularglutamate concentrations and changes in structural plasticity in the NAcore of CRS-experienced animals. These alterations were thought to underlie CRS-induced behavioral cross-sensitization to cocaine, since byrestoring glutamate transport in the NAcore with ceftriaxone, the facilitating influence of stress on the sensitized response to the psychomotor-stimulating effects of cocaine was blocked. These results emphasize the biological importance of GLT-1 in the NAcore as a vulnerability marker in the comorbidity between stress and substance use disorders.