COGNITIVE AND MOTOR DYSFUNCTION IN zQ175 HUNTINGTON´S DISEASE MICE

JULIETA BRUNO; FEDERICO LÓPEZ COUSELO; DIEGO RIVAS; MATEO PALMIERI; JULIETA SABA; LILA CARNIGLIA; DANIELA DURAND; MERCEDES LASAGA; CARLA CARUSO

Congreso; LXVII Reunión anual de la Sociedad Argentina de Investigación Clínica; 2022

Huntington’s Disease is a neurodegenerative genetic disorder caused by CAG repeat expansion in the huntingtin gene that generates motor, cognitive and psyquiatric symptoms in humans. In this work, our objective was to evaluate sex differences in cognitive and motor function of zQ175 knock-in (HD) and wild type (WT) mice at 4 or 8 months (M) of age. We tested their behavior by using the open field test, the gait analysis, and the novel object recognition (NOR) test.Results: In the open field test, HD female mice traveled less distance, moved more slowly (p