BECAS
DE FAZIO Rayen
congresos y reuniones científicas
Título:
Alterations in NHE1 overexpressing mitochondria
Autor/es:
DE FAZIO, RAYEN; CAROLINA CIANCIO; ALEJANDRO ORLOWSKI; ERNESTO ALEJANDRO AIELLO; CAROLINA JAQUENOD DE GIUSTI
Lugar:
La Plata
Reunión:
Congreso; ISHR Annual Meeting Latinamerica section; 2022
Resumen:
Mitochondria are not only implicated in energy production but also in pathological events.Mitochondrial dysfunction has been related to the development of several pathologies includingheart failure and diabetes. The Na+/H+ exchanger 1 (NHE1) is one of the main alkalinizingmechanisms in the heart and its hyperactivity has been observed in several heart conditions,including diabetic cardiomyopathy. In obese and diabetic mice mitochondria NHE1 expression isincreased despite similar cardiac levels, together with altered calcium handling reverted in thepresence of an NHE1 inhibitor.
