PERSONAL DE APOYO
PEREZ Ernesto Rafael
congresos y reuniones científicas
Título:
An inverse docking approach with biological networks to understand the effect of C. Citratus compounds on Chagas disease
Autor/es:
GÓMEZ CHÁVEZ, LEONARDO; CONTI, GERMÁN; PEREZ, ERNESTO RAFAEL; ANGELINA, EMILIO; PERUCHENA, NELIDA
Lugar:
Corrientes
Reunión:
Congreso; XII CAB2C Congreso Argentino de Bioinformática y Biología Computacional; 2022
Institución organizadora:
Asociación Argentina de Bioinformática y Biología Computacional
Resumen:
The chronic stage of Chagas disease is characterized by intense cardiomyopathy causedby infection by the parasite Trypanosoma cruzi. Cymbopogon citratus extracts have been shown to beeffective at this stage, relieving this pathology by reducing amastigote nets and inflammatory infiltrates in the cardiac tissue of mice. In this work, bioinformatic tools together with chemoinformatic and virtual screening tools were used to understand the mechanism of action at the molecular level ofCymbopogon citratus extract in chagasic cardiomyopathy.
