The inhibitory effect of Fasciola hepatica antigens on induced LPS-DC activation correlates with a decrease in p38 and STAT3 phosphorylation and is independent on NF-κB translocation

FALCÓN, CRISTIAN; CARRANZA, FRANCO; NUÑEZ, NICOLÁS; CERVI, LAURA.

Buenos Aires

Congreso; First Franco-Argentine Scienctific Meeting in Immunology; 2010

Sociedad Argentina de Inmunología

The ability of different Fasciola hepatica (Fh) antigens to diminish the classical TLR ligand dendritic cell (DC) activation has been demonstrated. However, little is know about the signals used for this helminth to bias DC activation toward a tolerogenic profile. The objective of this work was to investigate the signals involved in the modulation of F.h total extract (TE) to decrease the LPS induced DC maturation when these cells are simultaneously exposed to both stimuli (T/L). The T/L treatment of bone marrow derived DC induced a significant increase in IL-10 production (determined by ELISA) (Student T test p