EFFECT OF METRONOMIC CHEMOTHERAPY ON MICE WITH METABOLIC SYNDROME BEARING A MAMMARY ADENOCARCINOMA

HABIB, MARTIN JOSE; BARRANCO, MARIA MANUELA; SIGAL, NICOLAS; SYLVESTRE BEGNIS, MARIA; ZECCHINATI, F; DEL GIUDICE, ANTONELA; RICO, MARIA JOSE; ROZADOS, VIVIANA; SCHAROVSKY O, GRACIELA; VILLANUEVA, SSM; GARCÍA, F; MAINETTI LEANDRO

Rosario

Congreso; XX Congreso y XXXVIII Reunión Anual de la Sociedad de Biología de Rosario; 2019

Sociedad de Biología de Rosario

High fat diets cause obesity and metabolic syndrome (MS) and they are associated with breast cancer progression. Metronomicchemotherapy (MCT) is characterized by the chronic, equally spaced, administration of chemotherapeutic drugs, in doses significantlylower than the maximum tolerated dose, without extended rest periods. Our objective was to evaluate, in mice with MS and bearingthe M-406 mammary adenocarcinoma (M-406), the effect of MCT with cyclophosphamide (Cy). CBi male mice (5 weeks of age),were fed with a standard diet (Control, C) or with a diet with 40% calories of bovine fat (High Fat Diet, HFD), during all theexperiment. At 16 weeks, the development of MS was confirmed by body weight gain (P