CHRONIC STRESS EXPOSURE INCREASES DIABETES INCIDENCE AND ALTERS GUT MICROBIOTA IN NOD/ShiLtJ MICE

RUBINSTEIN MR; WYDRA L; BIANCHI MS; WALD MR; GENARO AM

Ciudad Autónoma de Buenos Aires

Congreso; Reunión Anual de Sociedades de Biociencias; 2022

Sociedad Argentina de Investigación Clínica (SAIC), Sociedad Argentina de Inmunología (SAI), Sociedad Argentina de Fisiología (SAFIS) , French-Argentine Immunology Congress (FAIC)

Type 1 diabetes (T1D) is characterized by impaired insulin secretion and it has been recognized the contribution of psychosocial factors (including chronic stress exposure) in T1D. Gut microbiota is the group of microorganisms (commensal, symbiotic and pathogenic) that we find in our gut. It participates in multiple functions and an association between unbalanced microbiota and several diseases, including diabetes, has been reported. NOD/ShiLtJ mice are a model for autoimmune type 1 diabetes. The aim of the present work is to study the effect of chronic stress in diabetes development and to characterize the microbiota alterations in NOD/ShiLtJ mice. For this purpose, the animals were subject to chronic stress (CS) by the application of aleatory and unpredictable stressors. NOD/ShiLtJ mice exposed to CS (NOD + CS) showed an increase in diabetes incidence (Long-rank test, p