Chalcones as inhibitors of phytopathogenic fungal in-vitro development

SANCHEZ, C; ARDANAZ, C; MASCOTTI, ML; KURINA-SANZ, MB; ORDEN, AA

San Luis

Otro; XXVII Reunion cientifica anual de la sociedad de biología de cuyo; 2009

In  the  search  of  novel  antifungal  compounds  derived  from  natural  products  leads,  a  family  of  22 chalcones was prepared in a “one step-one pot” procedure by condensation of methyl-aryl ketones and  aryl-aldehydes,  and  characterized  by mass  spectrometry  (MS). The  antifungal  activity  of  the family members was tested against the following series of phytopatogenic fungi: Six species of the Aspergillus genus (A. niger, A. terreus, A. flavus, A. parasiticus, A. candidus and A. fumigatus), two species of Penicillium (P. notatum and P. crysogenum) and Fusarium graminearum.