THYMIC STROMAL LYMPHOPOIETIN (TSLP) IS A TUMOR MICROENVIRONMENT MODULATOR: RELE- VANCE IN THE PATHOGENESIS OF GLIOBLASTOMA AS TUMOR IMMUNOMODULATOR

CORONEL, JUAN V; INFANTE CRUZ, ALEJANDRA; JANCIC, CAROLINA C; ROSSO, DAVID A; ROSATO, MICAELA; ITURRIZAGA, JUAN; RABADAN, ALEJANDRA T; REMES LENICOV, FEDERICO; SALAMONE, GABRIELA V

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2021; 2021

SAIC, SAI, AAFE y NANOMED-AR

Glioblastoma (GBM) is the most devastating brain tumor, with an associated poor prognosis. Despite the advances in surgery and other treatments, the survival of GBM patients has not improved significantly in the past three decades. Thymic stromal lymphopoietin (TSLP) is a cytokine produced primarily by activated epithelial cells and it has been shown to be a key factor in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. Furthermore, recent studies have found the participation of TSLP in inflammatory diseases and cancer. This work aimed to elucidate the relevance of TSLP in the interaction between neutrophils and GBM cells. For this purpose, human U251 cell line or tumoral cells obtained from a patient’s GBM biopsy (GBM-b) were co-cultured with human neutrophils. First, we observed a decrease in the neutrophils apoptosis when they were cocultured with the U251 cell line or the GBM-b cells in the presence of exogenous TSLP (p