IGF2-OMAs are a potential cause of hypoglycemia in infants

BRASLAVSKY, DEBORA; BALLERINI, MARÍA G; MARTIN AYELEN; RODRIGUEZ MARÍA EUGENIA; GIL, MELINA; MARTINO, FLORENCIA; KESELMAN, ANA; ROPELATO, MARÍA G; PENNISI, PATRICIA; BERGADÁ, IGNACIO

Buenos Aires

Congreso; 11th International Meeting of Paediatric Endocrinology (IMPE); 2023

Background: Persistent hypoglycemia in pediatric patients isthe clinical manifestation of different hormonal and metabolic disordersand expose them to a high risk of brain damage. Appropriatemanagement should include staggered strategy to achieve theunderlying etiology.Aim: To describe an infant with recurrent hypoglycemia due toStage 4 Neuroblastoma (4SNB) behaving as an “IGF2-OMA”.Case Report: A 2-month boy admitted with a huge high consistencyabdominal mass and multiple bluish cutaneous nodules.Male genitalia, Tanner stage I, testicular volume of 2 ml. 4SNB wasconfirmed. While being critically ill, recurrent hypoglycemic episodesoccurred (glycemia levels 13 to 36 mg/dL). Critical sampleshowed non-detectable insulin and C peptide, bOHbutirate 0.05mmol/L, NEFA 0.49 mmol/L, GH 0.27 ng/mL, IGF1