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Título:
Electric field effects in tumors: in vitro and in silico
Autor/es:
L. COLOMBO, S. DENGRA, D. FERNÁNDEZ SLEZAK, G. GONZÁLEZ, G. MARSHALL, E. MOCSKOS, F. V. MOLINA,
Lugar:
Argentina
Reunión:
Simposio; ISEHD2006 International Symposium of Electrohidrodinamic; 2006
Institución organizadora:
IEEE
Resumen:
AbstractThe electrochemical treatment (EChT) of tumors
consists in the passage of a direct electric current through
electrodes inserted locally in the tissue, which causes its necrosis.
The extreme pH changes induced had been proposed as the
main tumor destruction mechanism. Here we study ion transport
during the EChT through in vitro modeling with agar and
collagen gels, and in silico or numerical modeling using the
one-dimensional Nernst-Planck and Poisson equations describing
ion transport in a four-ion electrolyte under constant current
conditions. Experiments and simulations reveal that, under
EChT modeling, an initial condition with almost neutral pH
concentration becomes extremely alkaline and acid at the cathode
and anode, respectively, and from there the pH concentration
rapidly turns to its neutral values into the periphery. The
pH front tracking scales in time close to t
1/2, indicating a
diffusion-controlled process. These results could have significant
implications in a future design of optimal operative conditions
and dose planning of EChT therapy.