Development of a new murine model of metabolic syndrome after feeding with high-fat diet in female Cbi mice

BARRANCO, MARIA MANUELA; SYLVESTRE BEGNIS, MARIA; HABIB, MARTIN JOSE; LANZILOTTA, MAGDALENA; DEL GIUDICE, ANTONELA; RICO, MARIA JOSE; SCHAROVSKY O, GRACIELA; GARCÍA, FABIANA; MAINETTI LEANDRO; ROZADOS, VIVIANA

MAR DE PLATA

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIA 2019; 2019

It has been well established that obesity and overweight are major risk factors for several diseases, such as metabolic syndrome (MetS) and cancer. The MetS is characterized by insulin resistance, dyslipidemia and central obesity. Our aim was to generate an obese female model as a research tool. CBi is an inbred mouse strain generated in the Institute of Experimental Genetics, School of Medical Sciences, UNR. Eight weeks’ mice were randomly separated into two groups. Control group fed with a standard diet and HFD group with a high fat diet containing 40% of bovine fat (n=6/group). At week 20 (10 weeks earlier than in others models), body weight gain was higher in HFD (g; mean±SEM; 130±4.5) respect to Control (47±2.2) (P