Metabolic syndrome: development of a new murine model

BARRANCO, MARIA MANUELA; HABIB, MARTIN JOSE; DI CARLO, BIANCA; SIGAL, NICOLAS; SYLVESTRE BEGNIS, MARIA; ZECCHINATI, FELIPE; DEL GIUDICE, ANTONELA; RICO, MARIA JOSE; ROZADOS, VIVIANA; SCHAROVSKY O, GRACIELA; VILLANUEVA, SILVINA STELLA MARIS; MAINETTI LEANDRO; GARCÍA, FABIANA

MAR DE PLATA

Congreso; REUNIÓN CONJUNTA SAIC SAI SAFIS 218; 2018

The metabolic syndrome (MetS) is a serious health problem char- acterized by insulin resistance, dyslipidemia and central obesity. There is a strong correlation between obesity and increased risk for development MetS. Animal models are very useful tools in biomed- ical investigation. Diet-induced obesity models are used to develop MetS models. CBi is an inbred mouse strain generated by crossing BALB/c, Rockland, NIH and Swiss mice in the Institute of Experi- mental Genetics, School of Medical Sciences, UNR. Our aim was to emulate a model of MetS in CBi mice. Five weeks old male mice were randomly fed with a high fat diet containing 40% kcal from bovine fat (HFD group)or standard diet (Control group) (n=8/group). At week 16, body weight (BW) gain, showed higher values in HFD (%; 97±32) respect to Controls (54±2)(P