ALTERATIONS IN NHE1 OVEREXPRESSING MITOCHONDRIA

RAYEN DE FAZIO; CAROLINA CIANCIO; ALEJANDRO ORLOWSKI; ERNESTO ALEJANDRO AIELLO; CAROLINA JAQUENOD DE GIUSTI

Mar del Plata

Congreso; REUNIÓN CONJUNTA SAIC SAI&FAIC SAFIS 2022; 2022

Mitochondria are not only implicated in energy production but also in pathological events. Mitochondrial dysfunction has been related to the development of several pathologies including heart failure and diabetes. The Na+/H+ exchanger 1 (NHE1) is one of the main alkalinizing mechanisms in the heart and its hyperactivity has been observed in several heart conditions, including diabetic cardiomyopathy. In obese and diabetic mice mitochondria NHE1 expression is increased despite similar cardiac levels, together with altered calcium handling reverted in the presence of an NHE1 inhibitor.