3D printed polyesterurethane composite scaffolds for tissue engineering

LORES, NAYLA J.; ARÁOZ, BEATRIZ; HUNG HUNG, YUK MING X.; TALOU, MARIANO H.; BALLARRE, JOSEFINA; ABRAHAM, GUSTAVO A.; CARACCIOLO, PABLO C.

Mar del Plata

Congreso; 20º Congreso Internacional de Metalurgia y Materiales (SAM-CONAMET 2022); 2022

Asociación Argentina de Materiales - INTEMA

In this work, 3D printed composite scaffolds based on bioresorbable polyesterurethanes (SPEU) were developed for bone tissue engineering applications. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), a natural-based polyester synthesized using microbial fermentation of carbon-based feedstock, Bioglass 45S5(BG) and GC were incorporated in the filament formulation. Matrices based on SPEU composite filaments were successfully obtained by FDM. The desired geometry, pore size and porosity could be achieved by properly setting FDM parameters. The printed scaffolds showed dimensional stability and high reproducibility. We believe these findings may benefit the design and fabrication of advanced implants, where a lack of 3D printable biomaterials exists for use in tissue engineering applications. To improve the in vitro performance of the scaffolds, a surface modification to increase their hydrophilicity and promote cell adhesion and proliferation is being carried out.