CONICET | Buscador de Institutos y Recursos Humanos

Colorectal carcinogenesis (CRc) is a process that stems from geneticmutations induced by physical or chemical agents. Epidemiologicalstudies suggest that the consumption of some phytochemicalsof the diet could directly affect the development of the disease. Historically,there have been mixed positions in what concerns yerbamate?s pro or anti carcinogenic role. In 1991, the IARC classifiedhot mate as a probable carcinogenic beverage. In 2016, IARC againevaluated the carcinogenicity of mate under the hypothesis ?It isthe temperature of the water and not the plant that is associatedwith cancer?. Due to insufficient evidence, cold mate could not beclassified. There are no studies that evaluate the relation betweenconsumption of cold mate and the carcinogenesis process. The aimof our research was to evaluate whether the consumption of coldmate modulated CRc.To establish the model, we used 1,2-Dimethylhydrazine (DMH).Cold beverages of yerba mate extract (YMe) in a dose of 1.6 gr/kg/day and Maltodextrin (MD - excipient of extract), were administeredvia the drinking water. Male and female BALB/c mice were injectedwith DMH (20 mg/kg/week) subcutaneously once a week for 14weeks. Fourteen weeks after the last DMH injection, the animalswere sacrificed. After extracting the colons, polypoid lesions werecounted. Then, colon´s mice were examined histologically. Therewas a correlation between macroscopic and histologic results. Infemale mice we observed that 25% of the control group (MD + DMH)developed tubulovillous adenomas while, in the treated group (YM+ DMH) all animals presented normal mucosa. In male mice, 37.5%of the MD + DMH group and 42% of the YM + DMH group showedadenomas. It is the first study that reports, on the one hand, thatcold mate is not a carcinogenic beverage and on the other hand thatchronic consumption of YMe would have a preventive role in CRc infemale mice. Further studies are needed to understand sex-relateddifference

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