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KUNDA Patricia Elena

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Título:

Moesin controls cortical stiffening at the onset of mitosis, which is required for cell rounding and assembly of the mitotic spindle

Autor/es:

KUNDA, PATRICIA; ANDREW PELLING; TAO LIU; BAUM, BUZZ

Lugar:

Edimburgo

Reunión:

Congreso; The Dynamic Cell; 2017

Institución organizadora:

BSCB, BSDB & Gen Soc Joint Spring Meeting

Resumen:

During mitosis, cells undergo a sequence ofmorphological changes that include retraction of the cell margin, rounding,pole elongation, invagination of the equatorial zone, cleavage, separation andthe respreading of the two daughter cells. Although the molecular componentsand mechanical events driving later steps in this process are well understood,little is known about the molecular and cell processes that underlie retractionand cell rounding. We identify Moesin (the only member of theERM family in Drosophila) as a key player. We find that Moesin, whichcrosslinks actin filaments to the plasma membrane, is activated at the onset ofmitosis and is essential for cortical stiffening, retraction of the cell marginand rounding. Additionally, Moesin activation is sufficient to cause cellrounding and an increase of cortical stiffness in flat interphase cells.Finally, RNAi induced Moesin silencing reduction leads to aberrant spindlemorphology and abnormal chromosomes segregation, with a concomitant delay inthe onset of anaphase. We propose that Moesin plays a key role inmitotic progression by controlling cortical stiffness, cell rounding andmitotic spindle morphogeneis.

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