BECAS
GONZÁLEZ Agustina
congresos y reuniones científicas
Título:
NEW 1,3-DIHIDROXYACRIDONE DERIVATES: SYNTHESIS AND EVALUATION AS AKT INHIBITORS OF SIGNALING PATHWAY IN SKELETAL MUSCLE CELLS
Autor/es:
AGUSTINA GONZÁLEZ; IRAZOQUI, A. PAULA; MENÉNDEZ, CINTIA A.; STEINGRUBER, H. SEBASTIÁN; APPIGNANESI, GUSTAVO A.; BUITRAGO, CLAUDIA G.; GERBINO, DARÍO C.
Lugar:
Bahía Blanca
Reunión:
Jornada; III Jornadas de Posgrado del DBByF; 2023
Institución organizadora:
Departamento de Biología, Bioquímica y Farmacia - Universidad Nacional del Sur
Resumen:
PI3K/Akt signaling pathway is crucial in cell growth, survival, differentiation and tumorigenesis. This route constitutes an alternative and attractive therapeutic target for the development of new antitumor agents. An interesting strategy applied to the discovery of new drugs consists in the use of the so-called "privileged structures" such as acridones (dibenzo-4-pyridones) and their congeners, which represent a biocompatible system against different biological targets. Based on the acridone scaffold, four new prototypes (named 3a-3d) were efficiently synthesized following simple operating procedures and subsequently biologically tested in skeletal muscle (C2C12) and rhabdomyosarcoma (RD) cells.
