Thyroid hormones regulate cell proliferation and antitumor immunity in melanoma

HELENA STERLE; CAYROL F; DEBERNARDI M; GONZALEZ G; CREMASCHI G

Congreso; LXVI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA; 2021

Melanoma (ME) is the most severe type of skin cancer and despite immune checkpoint inhibitors provide exceptionally durable responses, only a limited number of patients benefit from it, making crucial the study of new compounds for ME treatment. Thyroid hormones (TH) influence tumor progression by direct actions on cancer cells, tumor microenvironment and antitumor immunity. Our first aim was to evaluate TH effect on the proliferation of human (A375 and WM35) and mouse (B16F10 and B16F1) ME cells. We found that physiological levels of TH induce 15 to 35% ME cell proliferation (p