DYNAMICS OF SOLUBLE IMMUNE MEDIATORS IN COVID-19 PATIENTS FROM AN ARGENTINEAN COHORT WITH MODERATE AND SEVERE SYMPTOMS

ALMADA, LAURA; ANGIOLINI, SOFÍA C; DHO, NICOLÁS DANIEL; DUTTO, JEREMIAS; GAZZONI, YAMILA; MANZONE, CLARISA ; MARÍN, CONSTANZA; PONCE, NICOLÁS E; IRIBARREN, PABLO; CERBÁN, FABIO; MORÓN, GABRIEL; AMEZCUA VESELY, CAROLINA; ANA, YAMILE; CERVI, LAURA; CHIAPPELO, LAURA; FOZZATTI, LAURA; ICELY, PAULA; MACCIONI, MARIANA; MENA, CRISTIAN; MONTES, CAROLINA; MOTRÁN, CRISTINA; RODRIGUEZ GALÁN, CECILIA; STEMPIN, CINTHIA; VIANO, MARÍA ESTEFANÍA; BERTONE, M; ABIEGA, CLAUDIO; ESCUDERO, DAIANA; KHAN, ADRIAN; CAEIRO, JUAN PABLO; ARROYO, DANIELA; MALETTO, BELKYS A; ACOSTA RODRIGUEZ, EVA; GRUPPI, ADRIANA; SOTOMAYOR, CLAUDIA

Congreso; Reunión Conjunta SAI - SAIC - AAFE - NANOMED.AR 2021; 2021

Sociedad Argentina de Inmunología

The cytokine storm, a form of systemic inflammatory response syndrome, is one of the most dreadful complications that can occur during COVID-19. In this work, we aimed at studying the occurrence of a cytokine storm in a cohort of COVID-19 patients (Cpts) from Córdoba (Argentine). During first wave, we collected sera from individuals with RT-PCR+ for SARS-CoV2 hospitalized in Hospital Privado with moderate (MOD) and severe (SEV) disease (n=62, aged 21-80 years) as well as healthy controls (HC n=24, age matched), to determine the concentrations of IL-1, IL-6, IL-8, IL-10, IL-12, IL-28A/B, IL-29, TNF, IP-10, IFN, IFN, IFN and GM-CSF by LEGENDplexTM. Males represented 74% of MOD and 67% of SEV Cpts. Hypertension (HT, 48%), obesity (31%), dyslipidemia (DL, 24%), and diabetes (24%) were the most frequent comorbidities. All cytokines, except IL-28A/B, were significantly increased in total Cpts in comparison with HC (p