ENRICHED ENVIRONMENT AS A NON-PHARMACOLOGICAL TOOL TO PREVENT CHANGES IN HIPPOCAMPAL OXIDATIVE STATE INDUCED BY DIFFERENT NOISE EXPOSURE SCHEDULES AT AN EARLY DEVELOPMENTAL AGE

MOLINA, SJ; CAPANI, F; GUELMAN, LR

Mar del Plata, Buenos Aires

Congreso; XXXII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2017

Sociedad Argentina de Investigación en Neurociencias

Previous results show different hippocampal (HC)-related behavioral alterations in noise-exposed rats. In addition, rearing animals in an enriched environment (EE) showed to be effective to prevent most of them. However, data of HC oxidative state after noise exposure have not obtained yet. Thus, the aim of the present work was to test a potential noise effect on HC oxidative state through the measurement of endogenous antioxidant enzymes in rats exposed to different schedules as well as the possible prevention of these changes by rearing in an EE.7-days-old rats were exposed to noise (95-97 dB, 2h) for one (N1) or five (N5) consecutive days. After weaning, groups of rats were transferred to EE or standard cages. One week later, levels of Trx1 and Trx2 -two antioxidant enzymes from the thioredoxin family- were tested. Results showed that Trx1 levels were increased in N1 and N5 animals. In contrast, rearing these animals in an EE was effective in preventing these changes. On the other hand, Trx2 levels were increased only in N5 animals and EE was successful in preventing these changes in N5 rats.These findings suggest that an oxidative imbalance might be triggered after noise exposure, being Trx1 more susceptible to noise impact since only one exposure was enough to alter its levels. Conversely, several consecutive noise exposures might be necessary to generate changes on Trx2 levels. Finally, EE seems to be an effective strategy to reverse noise-induced changes in HC oxidative state.