Sex differences: Is it possible to detect early cardiovascular risks in adolescent born from hypertensive mothers during pregnancy?

ZILBERMAN J; TOMAT A; CRAMER V; BERNER E; CANIFFI, C; DOMINGUEZ J; ARRANZ C; GAGLIARDI JA; ROMERO M

Conferencia; The American Physiological Society?s (APS) seventh conference on New Trends in Sex and Gender Medicine; 2021

The American Physiological Society?s (APS)

Hypertension has a high risk of causing complications during pregnancy and future risks for the mother as well as the new-born child. It is important to find out early damages in cardiovascular prevention in the future. Aims: To assess if there are early cardiovascular risks in adolescents of both sexes born from hypertensive or normotensive mothers during pregnancy. Methodology: In this study 69 patients (16-20 years old) 36 born from normotensive mothers were included 19 male (M) y 17 females ( F), age M 16.0±1.8 years Vs. F 16.0±2.5 and 33 patients born from hypertensive mothers,12 M y 21 F average age M 16.3 ±2.1 and F 16.1±2.1. Adolescents were assessed using Tanner scale (T) 4 and 5. Office BP, health survey, Echocardiogram, blood test, inflammatory markers (IM): neutrophils / lymphocytes (N/L), PCRu and oxidative stress, TBARS and Catalase enzyme activity (CAT) and Superoxide Dismutase enzyme activity (SOD)Results: in the health survey done on normotensive mother born children 3 M (15.8%) and no women presented hypertension. Hypertensive mother born children presented the following: 6 M (50%) and 3 F (14.3%) (p 0.029). Office BP on normotensive mother born children: M 126.3 ± 9.5 vs, F 112.7 ± 8.3 p