Comparison of cardiovascular changes in bitches suffering from cystic endometrial hyperplasia ? pyometra complex before and after ovariohysterectomy or medical treatment

BATISTA PR; GOBELLO C; ARIZMENDI A; ARIONI S; RUBE A; TÓRTORA M; BLANCO PG

Congreso; 23rd EVSSAR Congress; 2021

European Veterinary Society of Small Animal Reproduction

Introduction and objectiveIn dogs, cardiac structure and function, peripheral circulation and electrophysiology adjustments associated with uterine infection have not been reported so far. Therefore, the aim of the present study was to compare echocardiographic, hemodynamic and electrocardiographic changes of bitches suffering from cystic endometrial hyperplasia ? pyometra complex (CEH-P) before and after ovariohysterectomy or medical treatment. Materials and methodsSeventeen, 4 to 12 years old, intact bitches suffering from CEH-P were included in this study. In all the animals, primary cardiac diseases were ruled out. After diagnosis, the bitches were randomly allocated into two treatment groups: dogs that underwent ovariohysterectomy (OVH; n=9), and dogs medically treated (MED; n=8), which received cabergoline 5 μg/kg PO for 7 days and cloprostenol 1 μg/kg SC once a day for 14 days. In all the bitches, amoxicillin-clavulanate at 12.5 mg/kg PO was administrated twice a day for 14 days. The animals were echocardiographically, hemodynamically and electrocardiographically evaluated on Days -1, 3, 7, 14, 21 and 28. In OVH and MED, day 0 was defined as the day of surgery or the onset of medical treatment, respectively. To verify the comparability of the groups, comparisons with regard to body weight, age, body temperature, white blood cells count (WBC), presence of depression, anorexia, dehydration, polydipsia, polyuria, vomiting and diarrhea were performed by Student?s t-test and Chi square test. Echocardiographic and electrocardiographic variables and systolic blood pressure (SBP) were transformed to percentage change ([Final value-initial value/initial value]*100) and analyzed by ANOVA for repeated measures followed by Tukey test. ResultsBody weight, age, WBC and clinical signs did not differ between groups (P>0.1). On day -1, cardiovascular parameters were similar between OVH and MED (P>0.1). Percentage shortening fraction (P