Macrocyclic lactones: Endectocide compounds

LANUSSE, C.; LIFSCHITZ, A.; IMPERIALE, F.

Veterinary Pharmacology and Therapeutics

Wiley Blackwell

Lugar: Iowa; Año: 2018; p. 1102 - 1127

General pharmacology: avermectins and milbemycinsMechanism of action: ecto-endoparasiticidal activityPharmacokinetics -Exchange between bloodstream and target tissues -Metabolism. Bile and intestinal excretion. Involvement of drug transport systems. Pharmacokinetic-pharmacodynamic relationshipTherapeutic uses: animal species-specific considerationsResistanceAvailable pharmaceutical preparationsDrug and host-related factors affecting pharmacokinetics and efficacy in ruminantsTissue residues. Withdrawal timesSafety and toxicityEcotoxicological impactConcluding remarks