INVESTIGADORES
TALEVI Alan
capítulos de libros
Título:
Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations
Autor/es:
MANUEL COUYOUPETROU; MAURICIO E. DI IANNI; MELISA E. GANTNER; GUIDO PESCE; ROXANA PERONI ; ALAN TALEVI; LUIS E. BRUNO BLANCH
Libro:
Antiepileptic Drug Discovery Novel Approaches
Editorial:
Springer
Referencias:
Año: 2016; p. 237 - 258
Resumen:
About one third of the epileptic patients cannot control their symptoms with antiepileptic drugs, despite the introduction of more than 15 novel therapeutic agents to the market since 1990. The most studied hypothesisto explain the phenomenon of drug resistance in epilepsy maintains that it might be related to regional overactivity of efflux transporters from the ATPbindingcassette (ABC) superfamily at the blood?brain barrier and/or the epileptic foci. Here, we review scientific evidence supporting the transporter hypothesisalong with its limitations. We also cover some technical aspects of computational and experimental approaches used for the early detection of substrates of such efflux systems.
