CHAPTER XV: MESENCHYMAL STEM CELLS AND METASTATIC NICHES Title: Mesenchymal stem cells as regulators of the bone marrow and bone components. Running title: Mesenchymal stem cells and bone

MARTINEZ LM; LABOVSKY V; FERNÁNDEZ VALLONE VB; CHOI H; PHILLIPS C; AMORÓS M; CHASSEING NA

Mesenchymal stromal cells as tumor stromal modulators.

Elsevier Science Publishing Co Inc. Imprint: Academic Press Inc

Año: 2016; p. 1 - 552

Libro a publicar agosto del 2016. Mail of the Editorial Office---------- Forwarded message ----------From: Eppich, Lisa (ELS-CMA) l.eppich@elsevier.com. Date: 2016-03-11 9:35 GMT-03:00Subject: RE: Final chapter - Mesenchymal Stromal Cells as Tumor Stromal ModulatorsTo: N. Alejandra Chasseing. alejachase@gmail.com.-------Dear Dr. Chasseing,Your chapter has been reviewed and is now accepted for publication, thank you so much for your excellent work! Your chapter will now be typeset and copyedited, and you can expect to receive proofs in a few weeks.Thank you again for all of your work and efforts.Best,Lisa Lisa Eppich.Editorial Project ManagerBiomedical ResearchElsevier, Inc.50 Hampshire StreetCambridge, MA 02139Phone: 781-663-5286Email: l.eppich@elsevier.com.-----------------------------------------------------ABSTRACT: Even though the bone marrow mesenchymal stem cells and the endosteal and vascular hematopoietic niche have been an active area of study, the concept of the bone marrow/ bone microenvironment harboring a niche for solid metastatic tumor cells has only recently been considered. The hematopietic stem cell niche that is thought to constitute the solid tumor niche share many of the same structural and functional components, suggesting the possibility that the hematopoietic and tumor niche are one in the same. The mesenchymal stem cells or osteoprogenitor cells, as well as osteoblasts are critical components for each of these niches, and are important components for regulating cellular processes such as homing and migration, proliferation and survival, and quiescence and dormancy of tumor cells. Current understanding of the mesenchymal stem cell properties may provide more insight to better defining the solid tumor niche, specially in the development of the bone marrow and bone pre-metastatic niche. KEYWORDS: mesenchymal stem cells, hematopoietic stem cells, osteoblasts, osteoclasts, bone marrow, bone, tumor, pre-metastatic niche.