Inhaled particulate matter leads to myocardial dysfunction

EVELSON, PABLO; MARCHINI, TIMOTEO; GARCÉS, MARIANA; CÁCERES, LOURDES; MAGNANI, NATALIA; ALVAREZ, SILVIA

Biochemistry of oxidative stress

Springer

Año: 2016; p. 275 - 285

Epidemiological studies have shown that the exposure to environmentalparticulate matter (PM) is associated with increased cardiopulmonary mortalityrates. Daily changes in PM concentration have also been positively correlated withincreased hospitalizations due to lower respiratory diseases, ischemic cardiovascularevents, arrhythmias, and heart failure. Human and animal models have alsoshown a pulmonary and systemic inflammatory response and oxidative stress associatedwith the exposure to environmental particles which could, in turn, alter heartoxygen metabolism and cardiovascular function. Given that mitochondria play anessential role in cellular O2 and energetic metabolism, it has been suggested thatmitochondrial dysfunction is a key feature in the development of cardiac alterationsduring the exposure to PM. This chapter is focused in the discussion of the differentmechanisms triggered by PM exposure that may lead to myocardial dysfunction,emphasizing the role of the systemic proinflammatory mediators released after PMinhalation.