INVESTIGADORES
PEREZ Nestor Gustavo
capítulos de libros
Título:
Na+/H+ exchanger and myocardial hypertrophy
Autor/es:
CAMILIÓN DE HURTADO MC; PÉREZ NG; ENNIS IL; ÁLVAREZ BV; CINGOLANI HE
Libro:
Signal Transduction and Cardiac Hypertrophy
Editorial:
Kluwer Academic Publishers
Referencias:
Lugar: Boston; Año: 2003; p. 125 - 135
Resumen:
Na+/H+ exchanger (NHE) is hyperactive in the hypertensive hypertrophied myocardium. Regression of cardiac hypertrophy (CH) induced by prolonged antihypertensive therapy with compounds of different pharmacological profiles (angiotensin converting enzyme inhibition, slow calcium channel and angiotensin II type 1 receptor blockade) normalizes the hyperactivity of myocardial NHE. Chronic treatment with selective NHE-1 inhibitors induced the regression of CH in SHR. Considered as a whole, these data support the notion of a causal link between the hyperactivity of the NHE-1 and the development of CH. Key words: Na+/H+ exchanger; cardiac hypertrophy; hypertension.