Advances on Applications of Nanotechnology to Drug Delivery: A Biopharmaceutical Perspective

CAROLINA L. BELLERA; ANDREA V. ENRIQUE; ALAN TALEVI; LUIS E. BRUNO-BLANCH

Nanoscience and Computational Chemistry: Research Progress

CRC Press

Año: 2013; p. 1 - 24

Abstract: During the last fifteen years, revolutionary developments in the production of nanosized particles have triggered substantial expectations for their applications in medical diagnosis and drug-delivery. This chapter would present a comprehensive overview of different nanosystems (dendrimers, lipid-based nanoparticles, liposomes, inorganic nanoparticles) and their present and potential applications as drug delivery systems. Recent reports on the advantages of those systems in relation to correction of suboptimal pharmacokinetics and distribution and location of therapeutic agents to specific cells or tissues are discussed. A final discussion on safety concerns in relation to their use as pharmaceuticals is also presented.