INVESTIGADORES
TALEVI Alan
capítulos de libros
Título:
Higuchi Model
Autor/es:
ALAN TALEVI; MARÍA E. RUIZ
Libro:
The ADME Encyclopedia. A Comprehensive Guide on Biopharmacy and Pharmacokinetics
Editorial:
Springer Nature
Referencias:
Año: 2022; p. 519 - 523
Resumen:
The Higuchi equation is a mathematical model of drug release originally conceived to describe the release of a drug from a thin ointment film into the skin [1] (although it has been later applied to model drug release from other systems). Among other considerations, the model assumes that the initial drug concentration in the film is much higher than the solubility of the drug in the ointment base. Hence, drug release will encompass both drug dissolution and diffusion. Moreover, it is assumed that the dissolution of the drug within the ointment base will be rapid in comparison with its diffusion.
