ALCOBER?BOQUET, LUCIA; ZANG, TABEA; PIETSCH, LARISSA; SUESS, EVELYN; HARTMANN, MARKUS; PROSCHAK, EWGENIJ; GROSS, LISSY Z. F.; SACERDOTI, MARIANA; ZEUZEM, STEFAN; ROGOV, VLADIMIR V.; LEROUX, ALEJANDRO E.; PIIPER, ALBRECHT; BIONDI, RICARDO M.

The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B

Protein Science; Año: 2024 vol. 33

GONZÁLEZ, LORENA; DÍAZ, LUCÍA; POUS, JOAN; BAGINSKI, BLAZEJ; DURAN-CORBERA, ANNA; SCARPA, MARGHERITA; BRUN-HEATH, ISABELLE; IGEA, ANA; MARTIN-MALPARTIDA, PAU; RUIZ, LIDIA; PALLARA, CHIARA; ESGUERRA, MAURICIO; COLIZZI, FRANCESCO; MAYOR-RUIZ, CRISTINA; BIONDI, RICARDO M.; SOLIVA, ROBERT; MACIAS, MARIA J.; OROZCO, MODESTO; NEBREDA, ANGEL R.

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

NATURE COMMUNICATIONS; Año: 2023 vol. 14

SACERDOTI, MARIANA; GROSS, LISSY Z.F.; RILEY, ANDREW; ZEHNDER, KARIN; GHODE, ABHIJEET; KLINKE, SEBASTIÁN; ANAND, GANESH SRINIVASAN; PARIS, KRISTINA; WINKEL, ANGELIKA; HERBRAND, AMANDA K.; GODAGE, YASMIN; COZIER, GYLES E.; SÜß, EVELYN; SCHULZE, JÖRG O.; PASTOR-FLORES, DANIEL; BOLLINI, MARIELA; CAPPELLARI, MARÍA VICTORIA; SVERGUN, DMITRI; GRÄWERT, MELISSA A.; ARAMENDIA, PEDRO F.; LEROUX, ALEJANDRO E.; POTTER, BARRY V.L.; CAMACHO, CARLOS J.; BIONDI, RICARDO M.

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

Science Signaling; Año: 2023 vol. 16

LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

The choreography of protein kinase PDK1 and its diverse substrate dance partners

BIOCHEMICAL JOURNAL; Año: 2023 vol. 480 p. 1503 - 1532

VELNATI, SURESH; CENTONZE, SARA; GIRIVETTO, FEDERICO; CAPELLO, DANIELA; BIONDI, RICARDO M.; BERTONI, ALESSANDRA; CANTELLO, ROBERTO; RAGNOLI, BEATRICE; MALERBA, MARIO; GRAZIANI, ANDREA; BALDANZI, GIANLUCA

Identification of Key Phospholipids That Bind and Activate Atypical PKCs

Biomedicines; Lugar: Basilea; Año: 2021 vol. 9

DULTZ, GEORG; SRIKAKULAM, SANJAY K.; KONETSCHNIK, MICHAEL; SHIMAKAMI, TETSURO; DONCHEVA, NADEZHDA T.; DIETZ, JULIA; SARRAZIN, CHRISTOPH; BIONDI, RICARDO M.; ZEUZEM, STEFAN; TAMPÉ, ROBERT; KALININA, OLGA V.; WELSCH, CHRISTOPH

Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2021

MIAN, AFSAR ALI; HABERBOSCH, ISABELLA; KHAMAISIE, HAZEM; AGBARYA, ABED; PIETSCH, LARISSA; ESHEL, ELIZABEH; NAJIB, DALLY; CHIRICHES, CLAUDIA; OTTMANN, OLIVER GERHARD; HANTSCHEL, OLIVER; BIONDI, RICARDO M.; RUTHARDT, MARTIN; MAHAJNA, JAMAL

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K

ANNALS OF HEMATOLOGY; Año: 2021 vol. 100 p. 2023 - 2029

HARTMANN, MARKUS; HUBER, JESSICA; KRAMER, JAN S.; HEERING, JAN; PIETSCH, LARISSA; STARK, HOLGER; ODADZIC, DALIBOR; BISCHOFF, IRIS; FÜRST, ROBERT; SCHRÖDER, MARTIN; AKUTSU, MASATO; CHAIKUAD, APIRAT; DÖTSCH, VOLKER; KNAPP, STEFAN; BIONDI, RICARDO M.; ROGOV, VLADIMIR V.; PROSCHAK, EWGENIJ

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

JOURNAL OF MEDICINAL CHEMISTRY; Año: 2021 vol. 64 p. 3720 - 3746

LISA, MARÍA-NATALIA; SOGUES, ADRIÀ; BARILONE, NATHALIE; BAUMGART, MEIKE; GIL, MAGDALENA; GRAÑA, MARTÍN; DURÁN, ROSARIO; BIONDI, RICARDO M.; BELLINZONI, MARCO; BOTT, MICHAEL; ALZARI, PEDRO M.

A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG

mBio; Año: 2021 vol. 12

GROSS, LISSY Z.F.; SACERDOTI, MARIANA; PIIPER, ALBRECHT; ZEUZEM, STEFAN; LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

ACE2, the Receptor that Enables the Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators

CHEMMEDCHEM; Año: 2020

LEROUX, ALEJANDRO E.; BIONDI, RICARDO M.

Renaissance of Allostery to Disrupt Protein Kinase Interactions

TRENDS IN BIOCHEMICAL SCIENCES; Año: 2020 vol. 45 p. 27 - 41

DULTZ, GEORG; SHIMAKAMI, TETSURO; SCHNEIDER, MARKUS; MURAI, KAZUHISA; YAMANE, DAISUKE; MARION, ANTOINE; ZEITLER, TOBIAS M.; STROSS, CLAUDIA; GRIMM, CHRISTIAN; RICHTER, REBECCA M.; BÄUMER, KATRIN; YI, MINKYUNG; BIONDI, RICARDO M.; ZEUZEM, STEFAN; TAMPÉ, ROBERT; ANTES, IRIS; LANGE, CHRISTIAN M.; WELSCH, CHRISTOPH

Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2020 vol. 295 p. 13862 - 13874

GHODE, ABHIJEET; GROSS, LISSY Z.F.; TEE, WEI-VEN; GUARNERA, ENRICO; BEREZOVSKY, IGOR N.; BIONDI, RICARDO M.; ANAND, GANESH S.

Synergistic Allostery in Multiligand-Protein Interactions

BIOPHYSICAL JOURNAL; Año: 2020 vol. 119 p. 1833 - 1848

PLOTZ, GUIDO; LOPEZ-GARCIA, LAURA A.; BRIEGER, ANGELA; ZEUZEM, STEFAN; BIONDI, RICARDO M.

Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region

PLOS ONE; Año: 2020 vol. 15

LEROUX, ALEJANDRO E.; GROSS, LISSY Z. F.; SACERDOTI, MARIANA; BIONDI, RICARDO M.

Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling

ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY.; Lugar: Singapore; Año: 2019 vol. 1163 p. 279 - 311

PLELI, THOMAS; MONDORF, ANTONIA; FERREIROS, NEREA; THOMAS, DOMINIQUE; DVORAK, KAREL; BIONDI, RICARDO M.; HERINGDORF, DAGMAR MEYER ZU; ZEUZEM, STEFAN; GEISSLINGER, GERD; ZIMMERMANN, HERBERT; WAIDMANN, OLIVER; PIIPER, ALBRECHT

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY : INTERNATIONAL JOURNAL OF EXPERIMENTAL CELLULAR PHYSIOLOGY, BIOCHEMISTRY, AND PHARMACOLOGY.; Año: 2018 vol. 45 p. 2516 - 2528

WEßBECHER, ISABEL M.; HINRICHSEN, INGA; FUNKE, SEBASTIAN; OELLERICH, THOMAS; PLOTZ, GUIDO; ZEUZEM, STEFAN; GRUS, FRANZ H.; BIONDI, RICARDO M.; BRIEGER, ANGELA

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)

MOLECULAR CARCINOGENESIS.; Año: 2018 vol. 57 p. 1723 - 1734

RAAB, MONIKA; SANHAJI, MOURAD; PIETSCH, LARISSA; BÉQUIGNON, ISABELLE; HERBRAND, AMANDA K.; SÜß, EVELYN; GANDE, SANTOSH L.; CASPAR, BIRGIT; KUDLINZKI, DENIS; SAXENA, KRISHNA; SREERAMULU, SRIDHAR; SCHWALBE, HARALD; STREBHARDT, KLAUS; BIONDI, RICARDO M.

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds

ACS CHEMICAL BIOLOGY; Año: 2018 vol. 13 p. 1921 - 1931

PABON, NICOLAS A.; XIA, YAN; ESTABROOKS, SAMUEL K.; YE, ZHAOFENG; HERBRAND, AMANDA K.; SÜß, EVELYN; BIONDI, RICARDO M.; ASSIMON, VICTORIA A.; GESTWICKI, JASON E.; BRODSKY, JEFFREY L.; CAMACHO, CARLOS J.; BAR-JOSEPH, ZIV

Predicting protein targets for drug-like compounds using transcriptomics

PLOS COMPUTATIONAL BIOLOGY; Año: 2018 vol. 14

ARENCIBIA JM; FRÖHNER W; KRUPA M; PASTOR-FLORES D; MERKER P; OELLERICH T; NEIMANIS S; SCHMITHALS C; KÖBERLE V; SÜSS E; ZEUZEM S; STARK, H; PIIPER A; ODADZIC D; SCHULZE JO; BIONDI RM

An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms

ACS CHEMICAL BIOLOGY; Lugar: Washington; Año: 2017 vol. 12 p. 564 - 573

LEROUX, ALEJANDRO E.; SCHULZE, JÖRG O.; BIONDI, RICARDO M.

AGC kinases, mechanisms of regulation [U+200E]and innovative drug development

SEMINARS IN CANCER BIOLOGY; Año: 2017

HINRICHSEN, INGA; WEßBECHER, ISABEL M.; HUHN, MEIK; PASSMANN, SANDRA; ZEUZEM, STEFAN; PLOTZ, GUIDO; BIONDI, RICARDO M.; BRIEGER, ANGELA

Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2

MOLECULAR CARCINOGENESIS.; Año: 2017 vol. 56 p. 2663 - 2668

KHAGEH HOSSEINI, SABRINA; KOLTERER, STEFANIE; STEINER, MARLENE; VON MANSTEIN, VIKTORIA; GERLACH, KATHARINA; TROJAN, JÖRG; WAIDMANN, OLIVER; ZEUZEM, STEFAN; SCHULZE, JÖRG O.; HAHN, STEFFEN; STEINHILBER, DIETER; GATTERDAM, VOLKER; TAMPÉ, ROBERT; BIONDI, RICARDO M.; PROSCHAK, EWGENIJ; ZÖRNIG, MARTIN

Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE

BIOCHEMICAL PHARMACOLOGY; Año: 2017 vol. 146 p. 53 - 62

PASTOR-FLORES D; SCHULZE JO; BAHI A; CASAMAYOR A; BIONDI RM

Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1

BIOCHIMICA AND BIOPHYSICA ACTA; Año: 2016 vol. 1861 p. 249 - 259

SCHULZE JO; SALADINO G; BUSSCHOTS K; NEIMANIS S; SÜSS E; ODADZIC D; ZEUZEM S; HINDIE V; HERBRAND AK; LISA MN; ALZARI PM; GERVASIO FL; BIONDI RM

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

CHEMISTRY & BIOLOGY; Lugar: United States; Año: 2016 vol. 23 p. 1193 - 1205

HAUK S; KHAGEH HOSSEINI S; ACHENBACH J; BIONDI RM; PROSCHAK, E; ZÖRNIG M; ODADZIC D

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY.; Lugar: Amsterdam; Año: 2016 vol. 24 p. 5717 - 5729

LISA MN; GIL M; ANDRÉ-LEROUX G; BARILONE N; DURÁN N; BIONDI RM; ALZARI PM

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis.

STRUCTURE WITH FOLDING & DESIGN.; Lugar: United States; Año: 2015 vol. 23 p. 1039 - 1048

KROON E; SCHULZE JO; SÜSS E; CAMACHO CJ; BIONDI RM; DÖMLING A

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.

Angewandte Chemie; Lugar: Weinheim; Año: 2015 vol. 54

PASTOR-FLORES D; FERRER-DALMAU J; BAHÍ A; BOLEDA M; BIONDI RM; CASAMAYOR A

Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response

BMC GENOMICS; Lugar: Londres; Año: 2015

BAJER, MM; KUNZE, MM; BLEES, JS; BOKESCH, HR; CHEN, H; BRAUß, TF; DONG, Z; GUSTAFSON KR; BIONDI RM; HENRICH, CJ; MCMAHON, JB; COLBURN, NH; SCHMID, T; BRÜNE, B

Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor

BIOCHEMICAL PHARMACOLOGY; Lugar: Amsterdam; Año: 2014 vol. 88 p. 313 - 321

ZHANG H; NEIMANIS S; LOPEZ-GARCIA LA; ARENCIBIA JM; AMON S; STROBA A; ZEUZEM S; PROSCHAK, E; STARK, H; BAUER AF; BUSSCHOTS K; JØRGENSEN TJD; ENGEL M; SCHULZE JO; BIONDI RM

Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-terminal Domains and an Allosteric Small Compound

CHEMISTRY & BIOLOGY; Lugar: United States; Año: 2014 vol. 21 p. 754 - 765

KÖBERLE V; PLELI T; SCHMITHALS C; ALONSEO EA; HAUPENTHAL J; BÖNIG H; PEVELING-OBERHAG J; BIONDI RM; ZEUZEM S; KRONENBERGER B; WAIDMANN O; PIIPER A

Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers

PLOS ONE; Lugar: San Francisco; Año: 2013 vol. 8 p. 1 - 11

PASTOR-FLORES D; SCHULZE JO; BAHÍ A; GIACOMETTI R; FERRER-DALMAU J; PASSERON S; ENGEL M; SÜSS E; CASAMAYOR A; BIONDI RM

PIF-pocket as a target for C. albicans Pkh selective inhibitors

ACS CHEMICAL BIOLOGY; Lugar: Washington; Año: 2013 p. 2283 - 2293

ARENCIBIA JM; PASTOR-FLORES D; BAUER AF; ULZE JO; BIONDI RM

AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS; Lugar: Amsterdam; Año: 2013 p. 1302 - 1321

FABIAN AK; MÄRZ A; NEIMANIS S; BIONDI RM; KOZANY C; HAUSCH F

InterAKTions with FKBPs--mutational and pharmacological exploration

PLOS ONE; Lugar: San Francisco; Año: 2013 p. 1 - 11

WILHELM A; LOPEZ-GARCIA LA; BUSSCHOTS K; FRÖHNER W; MAURER F; BOETTCHER S; ZHANG H; SCHULZE JO; BIONDI RM; ENGEL M

2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.

JOURNAL OF MEDICINAL CHEMISTRY; Lugar: Washington; Año: 2012 p. 9817 - 9830

BUSSCHOTS K; LOPEZ-GARCIA LA; LAMMI C; STROBA A; ZEUZEM S; PIIPER A; ALZARI PM; NEIMANIS S; ARENCIBIA JM; ENGEL M; SCHULZE JO; BIONDI RM

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.

CHEMISTRY & BIOLOGY; Lugar: United States; Año: 2012 p. 1152 - 1163

BAUER AF; SONZOGNI S; MEYER L; ZEUZEM S; PIIPER A; BIONDI RM; BIONDI RM; NEIMANIS S

Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain.

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2012 p. 20590 - 20602

GIACOMETTI R; KRONBERG F; BIONDI RM; HERNÁNDEZ AI; PASSERON S

Cross regulation between Candida albicans catalytic and regulatory subunits of protein kinase A.

FUNGAL GENETICS AND BIOLOGY; Lugar: Amsterdam; Año: 2012 p. 74 - 85

RODRÍGUEZ-ASIAIN A; RUIZ-BABOT G; ROMERO W; CUBÍ R; ERAZO T; BIONDI RM; BAYASCAS JR; AGUILERA J; GÓMEZ N; GIL C; CLARO E; LIZCANO JM

Brain Specific Kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS; Lugar: Amsterdam; Año: 2011 p. 1124 - 1135

LOPEZ-GARCIA LA; SCHULZE JO; FRÖHNER W; ZHANG H; SÜSS E; WEBER N; NAVRATIL J; AMON S; HINDIE V; ZEUZEM S; JØRGENSEN TJ; ALZARI PM; NEIMANIS S; ENGEL M; BIONDI RM

Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket.

CHEMISTRY & BIOLOGY; Lugar: United States; Año: 2011 p. 1463 - 1473

FRÖHNER W; LOPEZ-GARCIA LA; NEIMANIS S; WEBER N; NAVRATIL J; MAURER F; STROBA A; ZHANG H; BIONDI RM; ENGEL M

4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.

JOURNAL OF MEDICINAL CHEMISTRY; Lugar: Washington; Año: 2011 p. 6714 - 6723

GIACOMETTI R; KRONBERG F; BIONDI RM; PASSERON S

Candida albicans Tpk1p and Tpk2p isoforms differentially regulate pseudohyphal development, biofilm structure, cell aggregation and adhesins expression.

YEAST; Lugar: LOndres; Año: 2011 p. 293 - 308

WAIDMANN O; PLELI T; DVORAK K; BAEHR C; BAEHR C; PLOTZ G; BIONDI RM; ZEUZEM S; PIIPER A

Inhibition of the equilibrative nucleoside transporter 1 and activation of A2A adenosine receptors by 8-(4-chlorophenylthio)-modified cAMP analogs and their hydrolytic products.

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2009 p. 32256 - 32263

DETTORI R; SONZOGNI S; MEYER L; LOPEZ-GARCIA LA; MORRICE NA; ZEUZEM S; ENGEL M; PIIPER A; NEIMANIS S; FRÖDIN M; BIONDI RM

Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2009 p. 30318 - 30327

HINDIE V; STROBA A; ZHANG H; LOPEZ-GARCIA LA; IDRISSOVA L; ZEUZEM S; HIRSCHBERG D; SCHAEFFER F; JØRGENSEN TJ; ENGEL M; ALZARI PM; BIONDI RM

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.

NATURE CHEMICAL BIOLOGY; Lugar: Londres; Año: 2009 p. 758 - 764

STROBA A; SCHAEFFER F; HINDIE V; LOPEZ-GARCIA LA; ADRIAN ; FRÖHNER W; HARTMANN RW; BIONDI RM; ENGEL M

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

JOURNAL OF MEDICINAL CHEMISTRY; Lugar: Washington; Año: 2009 p. 4683 - 4693

GIACOMETTI R; KRONBERG F; BIONDI RM; PASSERON S

Catalytic isoforms Tpk1 and Tpk2 of Candida albicans PKA have non-redundant roles in stress response and glycogen storage.

YEAST; Lugar: LOndres; Año: 2009 p. 273 - 285

HAUGE C; ANTAL TL; HIRSCHBERG D; DOEHN U; THORUP K; IDRISSOVA L; HANSEN K; JENSEN ON; JØRGENSEN TJ; BIONDI RM; FRÖDIN M

Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.

EMBO JOURNAL; Lugar: Londres; Año: 2007 p. 2251 - 2261

ENGEL M; HINDIE V; LOPEZ-GARCIA LA; STROBA A; SCHAEFFER F; ADRIAN I; IMIG J; IDRISSOVA L; NASTAINCZYK W; ZEUZEM S; ALZARI PM; HARTMANN RW; PIIPER A; BIONDI RM

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds.

EMBO JOURNAL; Lugar: Londres; Año: 2006 p. 5469 - 5480

PLOTZ G; WELSCH C; GIRON-MONZON L; FRIEDHOFF P; ALBRECHT M; PIIPER A; BIONDI RM; LENGAUER T; ZEUZEM S; RAEDLE J

Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.

NUCLEIC ACIDS RESEARCH; Lugar: Oxford; Año: 2006 p. 6574 - 6586

KIERMAYER S; BIONDI RM; IMIG J; PLOTZ G; HAUPENTHAL J; ZEUZEM S; PIIPER A

Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells.

MOLECULAR BIOLOGY OF THE CELL; Año: 2005 p. 5639 - 5648

BIONDI RM

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation.

TRENDS IN BIOCHEMICAL SCIENCES; Lugar: Londres; Año: 2004 p. 136 - 142

BIONDI RM; NEBREDA AR

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.

BIOCHEMICAL JOURNAL; Lugar: Londres; Año: 2003 p. 1 - 13

MEIMA, ME; BIONDI RM; SCHAPP, P

Identification of a novel type of cGMP phosphosiesterase that is defective in the chemotactic stmF mutants

MOLECULAR BIOLOGY OF THE CELL; Año: 2002 vol. 13 p. 3870 - 3877

BIONDI RM; KOMANDER, D; THOMAS, CC; LIZCANO, JM; DEAK, M; ALESSI, DR; VAN AALTEN, DM

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

EMBO JOURNAL; Lugar: Londres; Año: 2002 vol. 21 p. 4219 - 4228

FRÖDIN, M; ANTAL TL; DÜMMLER, BA; JENSEN, CL; DEAK, M; GAMMELTOFT, S; BIONDI RM

AGC kinases and PDK1 contain a phospho-Ser/Thr binding pocket that mediates activation by hydrophobic motif phosphorylation

EMBO JOURNAL; Lugar: Londres; Año: 2002 vol. 21 p. 5396 - 5407

HAMM, J; ALESSI, DR; BIONDI RM

Bi-functional, substrate mimicking RNA inhibits MSK1-mediated CREB phosphorylation and reveals Magnesium-ion dependent conformational changes of the kinase

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2002 vol. 277 p. 45793 - 45802

BIONDI RM; KIELOCH A; CURRIE, RA; DEAK, M; ALESSI, DR

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK but not PKB

EMBO JOURNAL; Lugar: Londres; Año: 2001 vol. 20 p. 4380 - 4390

FRAME, S; COHEN, P; BIONDI RM

A common phosphate binding site explains the substrate specificity of GSK3 and its inactivation by phosphorylation

MOLECULAR CELL; Lugar: United States; Año: 2001 vol. 7 p. 1321 - 1327

SCHNEIDER B; BIONDI RM; SARFATI R; AGOU F; GUERREIRO C; DEVILLE-BONNE D; VERON M

The mechanism of phosphorylation of anti-HIV D4T by nucleoside diphosphate kinase.

MOLECULAR PHARMACOLOGY; Lugar: Baltimore; Año: 2000 p. 948 - 953

BIONDI RM; CHEUNG, PCD; CASAMAYOR, A; DEAK, M; CURRIE, RA; ALESSI, DR

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

EMBO JOURNAL; Lugar: Londres; Año: 2000 vol. 19 p. 979 - 988

BALENDRAN, A; BIONDI RM; CHEUNG, PCD; CASAMAYOR A; DEAK, M; ALESSI, DR

A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cz (PKCz) and PKC-related Kinase 2 by PDK1

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 2000 vol. 275 p. 20806 - 20813

BIONDI RM; BAEHLER PJ; REYMOND CD; VÉRON M

Random insertion of GFP into the cAMP-dependent protein kinase regulatory subunit from Dictyostelium discoideum.

NUCLEIC ACIDS RESEARCH; Lugar: Oxford; Año: 1998 p. 4946 - 4952

BIONDI RM; SCHNEIDER B; PASSERON E; PASSERON S

Role of Mg2+ in nucleoside diphosphate kinase autophosphorylation.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Lugar: Amsterdam; Año: 1998 p. 85 - 92

XU Y; SELLAM O; MORÉRA S; SARFATI S; BIONDI RM; VÉRON M; JANIN J

X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 1997 p. 7162 - 7165

BIONDI RM; WALZ K; ISSINGER OG; ENGEL M; PASSERON S

Discrimination between acid and alkali-labile phosphorylated residues on Immobilon: phosphorylation studies of nucleoside diphosphate kinase.

ANALYTICAL BIOCHEMISTRY; Lugar: Amsterdam; Año: 1996 p. 165 - 171

BIONDI RM; ENGEL M; SAUANE M; WELTER C; ISSINGER OG; JIMÉNEZ DE ASÚA L; PASSERON S

Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2. Differential phosphorylation of NDP kinases in HeLa cells in culture.

FEBS LETTERS; Lugar: Amsterdam; Año: 1996 p. 183 - 187

BOURDAIS J; BIONDI RM; SARFATI S; GUERREIRO C; LASCU I; JANIN J; VÉRON M

Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase.

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda, Maryland; Año: 1996 p. 7887 - 7890

BIONDI RM; VERON M; WALZ K; PASSERON S

Candida albicans nucleoside-diphosphate kinase: purification and characterization.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS; Lugar: Amsterdam; Año: 1995 p. 187 - 194

PASSERON S; BIONDI RM

Isolation of Nucleoside Diphosphate Kinase from the Pathogenic Fungus Candida albicans

Journal of the Argentine Chemical Society; Lugar: Buenos Aires; Año: 1993 p. 187 - 194