NICOLAS GONZALO NUNEZ

IL-23 stabilizes an effector Treg cell program in the tumor microenvironment

Nature Immunology; Año: 2024 vol. 25 p. 512 - 524

NUÑEZ, NICOLÁS GONZALO

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

NATURE COMMUNICATIONS; Año: 2024 vol. 15

WYSS, NINA; BERNER, FIAMMA; WALTER, VINCENT; JOCHUM, ANN-KRISTIN; PURDE, METTE T.; ABDOU, MARIE-THERESE; SINNBERG, TOBIAS; HOFMEISTER, KATHRIN; POP, OLTIN T; HASAN ALI, OMAR; BAUER, JENS; CHENG, HUNG-WEI; LÜTGE, MECHTHILD; KLÜMPER, NIKLAS; DIEM, STEFAN; KOSALOGLU-YALCIN, ZEYNEP; ZHANG, YIZHENG; SELLMER, LAURA; MACEK, BORIS; KARBACH, JULIA; KÖNIG, DAVID; LÄUBLI, HEINZ; ZENDER, LARS; MEYER, BRITTA S.; DRIESSEN, CHRISTOPH; SCHÜRCH, CHRISTIAN M.; JOCHUM, WOLFRAM; AMARAL, TERESA; HEINZERLING, LUCIE; COZZIO, ANTONIO; HEGAZY, AHMED N.; SCHNEIDER, TINO; BRUTSCHE, MARTIN H; SETTE, ALESSANDRO; LENZ, TOBIAS L.; WALZ, JULIANE; RAMMENSEE, HANS-GEORG; FRÜH, MARTIN; JÄGER, ELKE; BECHER, BURKHARD; TUFMAN, AMANDA; NUÑEZ, NICOLAS; JOERGER, MARKUS; FLATZ, LUKAS

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade

AMERICAN JORUNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE; Año: 2024

NUÑEZ, NICOLAS GONZALO; BERNER, FIAMMA; FRIEBEL, EKATERINA; UNGER, SUSANNE; WYSS, NINA; GOMEZ, JULIA MARTINEZ; PURDE, METTE-TRIIN; NIEDERER, REBEKKA; PORSCH, MAXIMILIAN; LICHTENSTEIGER, CHRISTA; KRAMER, RAFAELA; ERDMANN, MICHAEL; SCHMITT, CHRISTINA; HEINZERLING, LUCIE; ABDOU, MARIE-THERESE; KARBACH, JULIA; SCHADENDORF, DIRK; ZIMMER, LISA; UGUREL, SELMA; KLÜMPER, NIKLAS; HÖLZEL, MICHAEL; POWER, LAURA; KREUTMAIR, STEFANIE; CAPONE, MARIAELENA; MADONNA, GABRIELE; CEVHERTAS, LACIN; HEIDER, ANJA; AMARAL, TERESA; HASAN ALI, OMAR; BOMZE, DAVID; DIMITRIOU, FLORENTIA; DIEM, STEFAN; ASCIERTO, PAOLO ANTONIO; DUMMER, REINHARD; JÄGER, ELKE; DRIESSEN, CHRISTOPH; LEVESQUE, MITCHELL PAUL; VAN DE VEEN, WILLEM; JOERGER, MARKUS; FRÜH, MARTIN; BECHER, BURKHARD; FLATZ, LUKAS

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors

Med; Año: 2023 vol. 4 p. 113 - 129

NUÑEZ, NICOLÁS GONZALO; SCHMID, JONAS; POWER, LAURA; ALBERTI, CHIARA; KRISHNARAJAH, SINDUYA; KREUTMAIR, STEFANIE; UNGER, SUSANNE; BLANCO, SEBASTIÁN; KONIGHEIM, BRENDA; MARÍN, CONSTANZA; ONOFRIO, LUISINA; KIENZLER, JENNY CHRISTINE; COSTA-PEREIRA, SARA; INGELFINGER, FLORIAN; CERBÁN, FABIO; CHIAPELLO, LAURA; MONTES, CAROLINA; MOTRÁN, CRISTINA; DUTTO, JEREMÍAS; ALMADA, LAURA; BOFFELLI, LUCÍA; SPINSANTI, LORENA; DÍAZ, ADRIÁN; RIVAROLA, MARÍA ELISA; BIOQ, JAVIER AGUILAR; BERANEK, MAURICIO; PASINOVICH, MARINA E.; CASTELLI, JUAN M.; VIZZOTTI, CARLA; SCHAEFER, MAXIMILIAN; VILLAR-VESGA, JUAN; MUNDT, SARAH; MERTEN, CARLA HELENA; SETHI, AAKRITI; WERTHEIMER, TOBIAS; LUTZ, MIRJAM; VANOAICA, DANUSIA; SOTOMAYOR, CLAUDIA; GRUPPI, ADRIANA; MÜNZ, CHRISTIAN; CARDOZO, DIEGO; BARBÁS, GABRIELA; LOPEZ, LAURA; CARREÑO, PAULA; CASTRO, GONZALO; RABOY, ELIAS; GALLEGO, SANDRA; MORÓN, GABRIEL; CERVI, LAURA; ACOSTA RODRIGUEZ, EVA V.; MALETTO, BELKYS A.; MACCIONI, MARIANA; BECHER, BURKHARD

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

NATURE IMMUNOLOGY (PRINT); Año: 2023

NÚÑEZ NICOLAS GONZALO

Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation—Immune signature correlates with response

British Journal of Haematology; Año: 2023 vol. 203 p. 264 - 281

NÚÑEZ NICOLAS GONZALO

Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells

OncoImmunology; Año: 2023 vol. 12

DIEBOLD, MARTIN; GALLI, EDOARDO; KOPF, ANDREAS; SANDERSON, NICHOLAS; CALLEGARI, ILARIA; INGELFINGER, FLORIAN; NÚÑEZ, NICOLÁS GONZALO; BENKERT, PASCAL; KAPPOS, LUDWIG; KUHLE, JENS; BECHER, BURKHARD; CLAASSEN, MANFRED; DERFUSS, TOBIAS

Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia

ANNALS OF NEUROLOGY; Año: 2022 vol. 91 p. 676 - 681

HO, JENNY N.H.G.; SCHMIDT, DOMINIK; LOWINUS, THERESA; RYOO, JEONGMIN; DOPFER, ELAINE-PASHUPATI; GONZALO NÚÑEZ, NICOLÁS; COSTA-PEREIRA, SARA; TOFFALORI, CRISTINA; PUNTA, MARCO; FETSCH, VIKTOR; WERTHEIMER, TOBIAS; RITTMANN, MARIE-CLAIRE; BRAUN, LUKAS M.; FOLLO, MARIE; BRIERE, CHRISTELLE; VINNAKOTA, JANAKI MANOJA; LANGENBACH, MARLENE; KOPPERS, FELICITAS; SHOUMARIYEH, KHALID; ENGEL, HELENA; RÜCKERT, TAMINA; MÄRKLIN, MELANIE; HOLZMAYER, SAMUEL; ILLERT, ANNA L.; MAGON, FEDERICA; ANDRIEUX, GEOFFROY; DUQUESNE, SANDRA; PFEIFER, DIETMAR; STANIEK, JULIAN; RIZZI, MARTA; MIETHING, CORNELIUS; KÖHLER, NATALIE; DUYSTER, JUSTUS; MENSSEN, HANS D.; BOERRIES, MELANIE; BUESCHER, JOERG M.; CABEZAS-WALLSCHEID, NINA; BLAZAR, BRUCE R.; APOSTOLOVA, PETYA; VAGO, LUCA; PEARCE, ERIKA L.; BECHER, BURKHARD; ZEISER, ROBERT

Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY - PRINT; Año: 2022 vol. 140 p. 1167 - 1181

VINCENTI, ILENA; PAGE, NICOLAS; STEINBACH, KARIN; YERMANOS, ALEXANDER; LEMEILLE, SYLVAIN; NUNEZ, NICOLAS; KREUTZFELDT, MARIO; KLIMEK, BOGNA; DI LIBERTO, GIOVANNI; EGERVARI, KRISTOF; PICCINNO, MARGOT; SHAMMAS, GHAZAL; MARIOTTE, ALEXANDRE; FONTA, NICOLAS; LIAUDET, NICOLAS; SHLESINGER, DANIELLE; LIUZZI, ANNA RITA; WAGNER, INGRID; SAADI, CYNTHIA; STADELMANN, CHRISTINE; REDDY, SAI; BECHER, BURKHARD; MERKLER, DORON

Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS

Science Translational Medicine; Año: 2022 vol. 14

NALIO RAMOS, RODRIGO; MISSOLO-KOUSSOU, YOANN; GERBER-FERDER, YOHAN; BROMLEY, CHRISTIAN P.; BUGATTI, MATTIA; NÚÑEZ, NICOLAS GONZALO; TOSELLO BOARI, JIMENA; RICHER, WILFRID; MENGER, LAURIE; DENIZEAU, JORDAN; SEDLIK, CHRISTINE; CAUDANA, PAMELA; KOTSIAS, FIORELLA; NIBORSKI, LETICIA L.; VIEL, SOPHIE; BOHEC, MYLÈNE; LAMEIRAS, SONIA; BAULANDE, SYLVAIN; LESAGE, LAËTITIA; NICOLAS, ANDRÉ; MESEURE, DIDIER; VINCENT-SALOMON, ANNE; REYAL, FABIEN; DUTERTRE, CHARLES-ANTOINE; GINHOUX, FLORENT; VIMEUX, LENE; DONNADIEU, EMMANUEL; BUTTARD, BÉNÉDICTE; GALON, JÉRÔME; ZELENAY, SANTIAGO; VERMI, WILLIAM; GUERMONPREZ, PIERRE; PIAGGIO, ELIANE; HELFT, JULIE

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

CELL; Año: 2022 vol. 185 p. 1189 - 1207

FALLEGGER, ANGELA; PRIOLA, MARTINA; ARTOLA-BORÁN, MARIELA; NÚÑEZ, NICOLÁS GONZALO; WILD, SEBASTIAN; GURTNER, ALESSANDRA; BECHER, BURKHARD; YOUSEFI, SHIDA; SIMON, HANS-UWE; ARNOLD, ISABELLE C.; MÜLLER, ANNE

TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge

MUCOSAL IMMUNOLOGY; Año: 2022 vol. 15 p. 504 - 514

KREUTMAIR, STEFANIE; KAUFFMANN, MANUEL; UNGER, SUSANNE; INGELFINGER, FLORIAN; NÚÑEZ, NICOLÁS GONZALO; ALBERTI, CHIARA; DE FEO, DONATELLA; KRISHNARAJAH, SINDUYA; FRIEBEL, EKATERINA; ULUTEKIN, CAN; BABAEI, SEPIDEH; GABORIT, BENJAMIN; LUTZ, MIRJAM; JURADO, NICOLE PUERTAS; MALEK, NISAR P.; GÖPEL, SIRI; ROSENBERGER, PETER; HÄBERLE, HELENE A.; AYOUB, IKRAM; AL-HAJJ, SALLY; CLAASSEN, MANFRED; LIBLAU, ROLAND; MARTIN-BLONDEL, GUILLAUME; BITZER, MICHAEL; ROQUILLY, ANTOINE; BECHER, BURKHARD

Preexisting comorbidities shape the immune response associated with severe COVID-19

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY; Año: 2022 vol. 150 p. 312 - 324

DIEBOLD, MARTIN; GALLI, EDOARDO; KOPF, ANDREAS; SANDERSON, NICHOLAS S.R.; CALLEGARI, ILARIA; BENKERT, PASCAL; NUÑEZ, NICOLAS GONZALO; INGELFINGER, FLORIAN; HERMS, STEFAN; CICHON, SVEN; KAPPOS, LUDWIG; KUHLE, JENS; BECHER, BURKHARD; CLAASSEN, MANFRED; DERFUSS, TOBIAS

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2022 vol. 119

GURTNER, ALESSANDRA; BORRELLI, COSTANZA; GONZALEZ-PEREZ, IGNACIO; BACH, KARSTEN; ACAR, ILHAN E.; NÚÑEZ, NICOLÁS G.; CREPAZ, DANIEL; HANDLER, KRISTINA; VU, VIVIAN P.; LAFZI, ATEFEH; STIRM, KRISTIN; RAJU, DEEKSHA; GSCHWEND, JULIA; BASLER, KONRAD; SCHNEIDER, CHRISTOPH; SLACK, EMMA; VALENTA, TOMAS; BECHER, BURKHARD; KREBS, PHILIPPE; MOOR, ANDREAS E.; ARNOLD, ISABELLE C.

Active eosinophils regulate host defence and immune responses in colitis

NATURE; Año: 2022

GATTI, GERARDO; BETTS, COURTNEY; ROCHA, DARÍO; NICOLA, MARIBEL; GRUPE, VERÓNICA; DITADA, CECILIA; NUÑEZ, NICOLAS G.; ROSELLI, EMILIANO; ARAYA, PAULA; DUTTO, JEREMÍAS; BOFFELLI, LUCIA; FERNÁNDEZ, ELMER; COUSSENS, LISA M.; MACCIONI, MARIANA

High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

BREAST CANCER RESEARCH; Año: 2021 vol. 23

TALLÓN DE LARA, PAULINO; CASTAÑÓN, HÉCTOR; VERMEER, MARIJNE; NÚÑEZ, NICOLÁS; SILINA, KARINA; SOBOTTKA, BETTINA; URDINEZ, JOAQUÍN; CECCONI, VIRGINIA; YAGITA, HIDEO; MOVAHEDIAN ATTAR, FARKHONDEH; HILTBRUNNER, STEFANIE; GLARNER, ISABELLE; MOCH, HOLGER; TUGUES, SÒNIA; BECHER, BURKHARD; VAN DEN BROEK, MARIES

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

NATURE COMMUNICATIONS; Año: 2021 vol. 12

KREUTMAIR, STEFANIE; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; INGELFINGER, FLORIAN; ALBERTI, CHIARA; DE FEO, DONATELLA; KRISHNARAJAH, SINDUYA; KAUFFMANN, MANUEL; FRIEBEL, EKATERINA; BABAEI, SEPIDEH; GABORIT, BENJAMIN; LUTZ, MIRJAM; JURADO, NICOLE PUERTAS; MALEK, NISAR P.; GOEPEL, SIRI; ROSENBERGER, PETER; HÄBERLE, HELENE A.; AYOUB, IKRAM; AL-HAJJ, SALLY; NILSSON, JAKOB; CLAASSEN, MANFRED; LIBLAU, ROLAND; MARTIN-BLONDEL, GUILLAUME; BITZER, MICHAEL; ROQUILLY, ANTOINE; BECHER, BURKHARD

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

IMMUNITY; Año: 2021

AGLIARDI, GIULIA; LIUZZI, ANNA RITA; HOTBLACK, ALASTAIR; DE FEO, DONATELLA; NÚÑEZ, NICOLÁS; STOWE, CASSANDRA L.; FRIEBEL, EKATERINA; NANNINI, FRANCESCO; RINDLISBACHER, LUKAS; ROBERTS, THOMAS A.; RAMASAWMY, RAJIV; WILLIAMS, IWAN P.; SIOW, BERNARD M.; LYTHGOE, MARK F.; KALBER, TAMMY L.; QUEZADA, SERGIO A.; PULE, MARTIN A.; TUGUES, SONIA; STRAATHOF, KARIN; BECHER, BURKHARD

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

NATURE COMMUNICATIONS; Año: 2021 vol. 12

PFISTER, DOMINIK; NÚÑEZ, NICOLÁS GONZALO; PINYOL, ROSER; GOVAERE, OLIVIER; PINTER, MATTHIAS; SZYDLOWSKA, MARTA; GUPTA, REVANT; QIU, MENGJIE; DECZKOWSKA, ALEKSANDRA; WEINER, ASSAF; MÜLLER, FLORIAN; SINHA, ANKIT; FRIEBEL, EKATERINA; ENGLEITNER, THOMAS; LENGGENHAGER, DANIELA; MONCSEK, ANJA; HEIDE, DANIJELA; STIRM, KRISTIN; KOSLA, JAN; KOTSILITI, ELENI; LEONE, VALENTINA; DUDEK, MICHAEL; YOUSUF, SUHAIL; INVERSO, DONATO; SINGH, INDRABAHADUR; TEIJEIRO, ANA; CASTET, FLORIAN; MONTIRONI, CARLA; HABER, PHILIPP K.; TINIAKOS, DINA; BEDOSSA, PIERRE; COCKELL, SIMON; YOUNES, RAMY; VACCA, MICHELE; MARRA, FABIO; SCHATTENBERG, JÖRN M.; ALLISON, MICHAEL; BUGIANESI, ELISABETTA; RATZIU, VLAD; PRESSIANI, TIZIANA; DALESSIO, ANTONIO; PERSONENI, NICOLA; RIMASSA, LORENZA; DALY, ANN K.; SCHEINER, BERNHARD; POMEJ, KATHARINA; KIRSTEIN, MARTHA M.; VOGEL, ARNDT; PECK-RADOSAVLJEVIC, MARKUS; HUCKE, FLORIAN; FINKELMEIER, FABIAN; WAIDMANN, OLIVER; TROJAN, JÖRG; SCHULZE, KORNELIUS; WEGE, HENNING; KOCH, SANDRA; WEINMANN, ARNDT; BUETER, MARCO; RÖS

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

NATURE; Año: 2021 vol. 592 p. 450 - 456

REGEN, TOMMY; ISAAC, SANDRINE; AMORIM, ANA; NÚÑEZ, NICOLÁS GONZALO; HAUPTMANN, JUDITH; SHANMUGAVADIVU, ARTHI; KLEIN, MATTHIAS; SANKOWSKI, ROMAN; MUFAZALOV, ILGIZ A.; YOGEV, NIR; HUPPERT, JULA; WANKE, FLORIAN; WITTING, MICHAEL; GRILL, ALEXANDRA; GÁLVEZ, ERIC J.C.; NIKOLAEV, ALEXEI; BLANFELD, MICHAELA; PRINZ, IMMO; SCHMITT-KOPPLIN, PHILIPPE; STROWIG, TILL; REINHARDT, CHRISTOPH; PRINZ, MARCO; BOPP, TOBIAS; BECHER, BURKHARD; UBEDA, CARLES; WAISMAN, ARI

IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Science Immunology; Año: 2021 vol. 6

LIGEON, LAURE-ANNE; PENA-FRANCESCH, MARIA; VANOAICA, LILIANA DANUSIA; NÚÑEZ, NICOLÁS GONZALO; TALWAR, DEEPTI; DICK, TOBIAS P.; MÜNZ, CHRISTIAN

Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

NATURE COMMUNICATIONS; Año: 2021 vol. 12

DUCIMETIÈRE, LAURA; LUCCHIARI, GIULIA; LITSCHER, GIOANA; NATER, MARC; HEEB, LAURA; NUÑEZ, NICOLÁS GONZALO; WYSS, LAURA; BURRI, DOMINIK; VERMEER, MARIJNE; GSCHWEND, JULIA; MOOR, ANDREAS E.; BECHER, BURKHARD; VAN DEN BROEK, MARIES; TUGUES, SONIA

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2021 vol. 118

INGELFINGER, FLORIAN; KRISHNARAJAH, SINDUYA; KRAMER, MICHAEL; UTZ, SEBASTIAN G.; GALLI, EDOARDO; LUTZ, MIRJAM; ZWICKY, PASCALE; AKARCA, AYSE U.; JURADO, NICOLE PUERTAS; ULUTEKIN, CAN; BAMERT, DAVID; WIDMER, CORINNE C.; PICCOLI, LUCA; SALLUSTO, FEDERICA; NÚÑEZ, NICOLÁS G.; MARAFIOTI, TERESA; SCHNEITER, DIDIER; OPITZ, ISABELLE; LANZAVECCHIA, ANTONIO; JUNG, HANS H.; DE FEO, DONATELLA; MUNDT, SARAH; SCHREINER, BETTINA; BECHER, BURKHARD

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

ACTA NEUROPATHOLOGICA; Año: 2021 vol. 141 p. 901 - 915

RAMELLO, MARIA C.; NÚÑEZ, NICOLÁS G.; TOSELLO BOARI, JIMENA; BOSSIO, SABRINA N.; CANALE, FERNANDO P.; ABRATE, CAROLINA; PONCE, NICOLAS; DEL CASTILLO, ANDRÉS; LEDESMA, MARTA; VIEL, SOPHIE; RICHER, WILFRID; SEDLIK, CHRISTINE; TIRABOSCHI, CAROLINA; MUÑOZ, MARCOS; COMPAGNO, DANIEL; GRUPPI, ADRIANA; ACOSTA RODRÍGUEZ, EVA V.; PIAGGIO, ELIANE; MONTES, CAROLINA L.

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients

Frontiers in Immunology; Año: 2021 vol. 12

STIRM, KRISTIN; LEARY, PETER; BERTRAM, KATRIN; NÚÑEZ, NICOLÁS GONZALO; WÜST, DARIA; BOUDESCO, CHRISTOPHE; VERHOEYEN, ELS; ZENZ, THORSTEN; BECHER, BURKHARD; MENTER, THOMAS; TZANKOV, ALEXANDAR; MÜLLER, ANNE

Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma

OncoImmunology; Año: 2021 vol. 10

MYBURGH, RENIER; KIEFER, JONATHAN D.; RUSSKAMP, NORMAN F.; MAGNANI, CHIARA F.; NUÑEZ, NICOLÁS; SIMONIS, ALEXANDER; PFISTER, SUREMA; WILK, C. MATTHIAS; MCHUGH, DONAL; FRIEMEL, JULIANE; MÜLLER, ANTONIA M.; BECHER, BURKHARD; MÜNZ, CHRISTIAN; VAN DEN BROEK, MARIES; NERI, DARIO; MANZ, MARKUS G.

Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells

LEUKEMIA; Año: 2020 vol. 34 p. 2688 - 2703

ASLAN, KATRIN; TURCO, VERENA; BLOBNER, JENS; SONNER, JANA K.; LIUZZI, ANNA RITA; NÚÑEZ, NICOLÁS GONZALO; DE FEO, DONATELLA; KICKINGEREDER, PHILIPP; FISCHER, MANUEL; GREEN, ED; SADIK, AHMED; FRIEDRICH, MIRCO; SANGHVI, KHWAB; KILIAN, MICHAEL; CICHON, FREDERIK; WOLF, LARA; JÄHNE, KRISTINE; VON LANDENBERG, ANNA; BUNSE, LUKAS; SAHM, FELIX; SCHRIMPF, DANIEL; MEYER, JOCHEN; ALEXANDER, ALLEN; BRUGNARA, GIANLUCA; RÖTH, RALPH; PFLEIDERER, KIRA; NIESLER, BEATE; VON DEIMLING, ANDREAS; OPITZ, CHRISTIANE; BRECKWOLDT, MICHAEL O.; HEILAND, SABINE; BENDSZUS, MARTIN; WICK, WOLFGANG; BECHER, BURKHARD; PLATTEN, MICHAEL

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

NATURE COMMUNICATIONS; Año: 2020 vol. 11

GEORGANAKI, MARIA; RAMACHANDRAN, MOHANRAJ; TUIT, SANDER; NÚÑEZ, NICOLÁS GONZALO; KARAMPATZAKIS, ALEXANDROS; FOTAKI, GRAMMATIKI; VAN HOOREN, LUUK; HUANG, HUA; LUGANO, ROBERTA; ULAS, THOMAS; KAUNISTO, AURA; HOLLAND, ERIC C; ELLMARK, PETER; MANGSBO, SARA M; SCHULTZE, JOACHIM; ESSAND, MAGNUS; TUGUES, SONIA; DIMBERG, ANNA

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

OncoImmunology; Año: 2020 vol. 9

NÚÑEZ, NICOLAS GONZALO; TOSELLO BOARI, JIMENA; RAMOS, RODRIGO NALIO; RICHER, WILFRID; CAGNARD, NICOLAS; ANDERFUHREN, CYRILL DIMITRI; NIBORSKI, LETICIA LAURA; BIGOT, JEREMY; MESEURE, DIDIER; DE LA ROCHERE, PHILIPPE; MILDER, MAUD; VIEL, SOPHIE; LOIRAT, DELPHINE; PÉROL, LOUIS; VINCENT-SALOMON, ANNE; SASTRE-GARAU, XAVIER; BURKHARD, BECHER; SEDLIK, CHRISTINE; LANTZ, OLIVIER; AMIGORENA, SEBASTIAN; PIAGGIO, ELIANE

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

NATURE COMMUNICATIONS; Año: 2020 vol. 11

FRIEBEL, EKATERINA; KAPOLOU, KONSTANTINA; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; UTZ, SEBASTIAN; RUSHING, ELISABETH JANE; REGLI, LUCA; WELLER, MICHAEL; GRETER, MELANIE; TUGUES, SONIA; NEIDERT, MARIAN CHRISTOPH; BECHER, BURKHARD

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

CELL; Año: 2020 vol. 181 p. 1626 - 1642

BOURDELY, PIERRE; ANSELMI, GIORGIO; VAIVODE, KRISTINE; RAMOS, RODRIGO NALIO; MISSOLO-KOUSSOU, YOANN; HIDALGO, SOFIA; TOSSELO, JIMENA; NUÑEZ, NICOLAS; RICHER, WILFRID; VINCENT-SALOMON, ANNE; SAXENA, ALKA; WOOD, KRISTIE; LLADSER, ALVARO; PIAGGIO, ELIANE; HELFT, JULIE; GUERMONPREZ, PIERRE

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

IMMUNITY; Año: 2020 vol. 53 p. 335 - 352

GALLI, EDOARDO; FRIEBEL, EKATERINA; INGELFINGER, FLORIAN; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; BECHER, BURKHARD

The end of omics? High dimensional single cell analysis in precision medicine

EUROPEAN JOURNAL OF IMMUNOLOGY; Año: 2019

CAUDANA, PAMELA; NÚÑEZ, NICOLAS; DELAROCHERE, PHILIPPE; PINTO, ANAÏS; DENIZEAU, JORDAN; ALONSO, RUBY; NIBORSKI, LETICIA; LANTZ, OLIVIER; SEDLIK, CHRISTINE; PIAGGIO, ELIANE

IL2/anti-IL2 complex combined with CTLA-4, but not PD-1, blockade rescues antitumor NK cell function by regulatory T-cell modulation

Cancer Immunology Research; Año: 2019

HUTMACHER, CORNELIA; NÚÑEZ, NICOLAS; LIUZZI, ANNA RITA; BECHER, BURKHARD; NERI, DARIO

Targeted delivery of IL2 to the tumor stroma potentiates the action of immune checkpoint inhibitors by preferential activation of NK and CD8+ T cells

Cancer Immunology Research; Año: 2019

ROSELLI, EMILIANO; ARAYA, PAULA; NÚÑEZ, NICOLÁS GONZALO; GATTI, GERARDO; GRAZIANO, FRANCESCA; SEDLIK, CHRISTINE; BENAROCH, PHILIPPE; PIAGGIO, ELIANE; MACCIONI, MARIANA

TLR3 Activation of Intratumoral CD103+ Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity

Frontiers in Immunology; Año: 2019 vol. 10

CHATTERJEE, BITHI; DENG, YUN; HOLLER, ANGELIKA; NUNEZ, NICOLAS; AZZI, TARIK; VANOAICA, LILIANA DANUSIA; MÜLLER, ANNE; ZDIMEROVA, HANA; ANTSIFEROVA, OLGA; ZBINDEN, ANDREA; CAPAUL, RICCARDA; DREYER, JOHANNES H.; NADAL, DAVID; BECHER, BURKHARD; ROBINSON, MARK D.; STAUSS, HANS; MÜNZ, CHRISTIAN

CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo

PLOS Pathogens; Año: 2019 vol. 15

BRUMMELMAN, JOLANDA; HAFTMANN, CLAUDIA; NÚÑEZ, NICOLÁS GONZALO; ALVISI, GIORGIA; MAZZA, EMILIA M. C.; BECHER, BURKHARD; LUGLI, ENRICO

Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry

NATURE PROTOCOLS; Año: 2019

MERLOTTI, ANTONELA; MALIZIA, ALVARO LÓPEZ; MICHEA, PAULA; BONTE, PIERRE-EMMANUEL; GOUDOT, CHRISTEL; CARREGAL, MARÍA SOL; NUÑEZ, NICOLÁS; SEDLIK, CHRISTINE; CEBALLOS, ANA; SOUMELIS, VASSILI; AMIGORENA, SEBASTIÁN; GEFFNER, JORGE; PIAGGIO, ELIANE; SABATTE, JUAN

Aberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)

OncoImmunology; Año: 2019 vol. 8

HÜLSDÜNKER, JAN; THOMAS, OLIVER S.; HARING, EILEEN; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; TUGUES, SONIA; GAO, ZHAN; DUQUESNE, SANDRA; CYWES-BENTLEY, COLETTE; OYARDI, OZLEM; KIRSCHNEK, SUSANNE; SCHMITT-GRAEFF, ANNETTE; PABST, OLIVER; KOENECKE, CHRISTIAN; DUYSTER, JUSTUS; APOSTOLOVA, PETYA; BLASER, MARTIN J.; BECHER, BURKHARD; PIER, GERALD B.; HÄCKER, GEORG; ZEISER, ROBERT

Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2019 vol. 116 p. 20700 - 20706

ARAYA, PAULA; WAUGH, KATHERINE A.; SULLIVAN, KELLY D.; NÚÑEZ, NICOLÁS G.; ROSELLI, EMILIANO; SMITH, KEITH P.; GRANRATH, ROSS E.; RACHUBINSKI, ANGELA L.; ESTRADA, BELINDA ENRIQUEZ; BUTCHER, ERIC T.; MINTER, ROSS; TUTTLE, KATHRYN D.; BRUNO, TULLIA C.; MACCIONI, MARIANA; ESPINOSA, JOAQUÍN M.

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2019 vol. 116 p. 24231 - 24241

LÍNDEZ, ADRIÀ-ARNAU MARTÍ; DUNAND-SAUTHIER, ISABELLE; CONTI, MARK; GOBET, FLORIAN; NÚÑEZ, NICOLÁS; HANNICH, J. THOMAS; RIEZMAN, HOWARD; GEIGER, ROGER; PIERSIGILLI, ALESSANDRA; HAHN, KERSTIN; LEMEILLE, SYLVAIN; BECHER, BURKHARD; DE SMEDT, THIBAUT; HUGUES, STÉPHANIE; REITH, WALTER

Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy

JCI Insight; Año: 2019 vol. 4

CANALE, FERNANDO P.; RAMELLO, MARÍA C.; NÚÑEZ, NICOLÁS; FURLAN, CINTIA L. ARAUJO; BOSSIO, SABRINA N.; SERRÁN, MELISA GOROSITO; BOARI, JIMENA TOSELLO; DEL CASTILLO, ANDRÉS; LEDESMA, MARTA; SEDLIK, CHRISTINE; PIAGGIO, ELIANE; GRUPPI, ADRIANA; RODRÍGUEZ, EVA V. ACOSTA; MONTES, CAROLINA L.

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells

CANCER RESEARCH; Año: 2018 vol. 78 p. 115 - 128

ALONSO, RUBY; FLAMENT, HÉLOÏSE; LEMOINE, SÉBASTIEN; SEDLIK, CHRISTINE; BOTTASSO, EMANUEL; PÉGUILLET, ISABEL; PRÉMEL, VIRGINIE; DENIZEAU, JORDAN; SALOU, MARION; DARBOIS, AURÉLIE; NÚÑEZ, NICOLÁS GONZALO; SALOMON, BENOIT; GROSS, DAVID; PIAGGIO, ELIANE; LANTZ, OLIVIER

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

NATURE COMMUNICATIONS; Año: 2018 vol. 9

CANALE, FERNANDO P.; RAMELLO, MARÍA C.; NÚÑEZ, NICOLÁS; BOSSIO, SABRINA N.; PIAGGIO, ELIANE; GRUPPI, ADRIANA; RODRÍGUEZ, EVA V. ACOSTA; MONTES, CAROLINA L.

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells—Response

CANCER RESEARCH; Año: 2018

TOSELLO BOARI, JIMENA; ARAUJO FURLAN, CINTIA L.; FIOCCA VERNENGO, FACUNDO; RODRIGUEZ, CONSTANZA; RAMELLO, MARÍA C.; AMEZCUA VESELY, MARÍA C.; GOROSITO SERRÁN, MELISA; NUÑEZ, NICOLÁS G.; RICHER, WILFRID; PIAGGIO, ELIANE; MONTES, CAROLINA L.; GRUPPI, ADRIANA; ACOSTA RODRÍGUEZ, EVA V.

IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection

Frontiers in Immunology; Año: 2018 vol. 9

TUGUES, SONIA; AMORIM, ANA; SPATH, SABINE; MARTIN-BLONDEL, GUILLAUME; SCHREINER, BETTINA; DE FEO, DONATELLA; LUTZ, MIRJAM; GUSCETTI, FRANCO; APOSTOLOVA, PETYA; HAFTMANN, CLAUDIA; HASSELBLATT, PETER; NÚÑEZ, NICOLAS G.; HOTTIGER, MICHAEL O.; VAN DEN BROEK, MARIES; MANZ, MARKUS G.; ZEISER, ROBERT; BECHER, BURKHARD

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells

Science Translational Medicine; Año: 2018 vol. 10

FRAZAO, ALEXANDRA; MESSAOUDENE, MERIEM; NÚÑEZ, NICOLAS; DULPHY, NICOLAS; ROUSSIN, FRANCE; SEDLIK, CHRISTINE; ZITVOGEL, LAURENCE; PIAGGIO, ELIANE; TOUBERT, ANTOINE; CAIGNARD, ANNE

CD16+NKG2Ahigh Natural Killer cells infiltrate breast cancer draining lymph nodes

Cancer Immunology Research; Año: 2018

TRUCCO, LUCAS DANIEL; ROSELLI, EMILIANO; ARAYA, PAULA; NUÑEZ, NICOLÁS GONZALO; MENA, HEBE AGUSTINA; BOCCO, JOSÉ LUIS; NEGROTTO, SOLEDAD; MACCIONI, MARIANA

Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma

PLOS ONE; Año: 2017 vol. 12

BARBARIN, ALICE; CAYSSIALS, EMILIE; JACOMET, FLORENCE; NUNEZ, NICOLAS GONZALO; BASBOUS, SARA; LEFÈVRE, LUCIE; ABDALLAH, MYRIAM; PICCIRILLI, NATHALIE; MORIN, BENJAMIN; LAVOUE, VINCENT; CATROS, VÉRONIQUE; PIAGGIO, ELIANE; HERBELIN, ANDRÉ; GOMBERT, JEAN-MARC

Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases

Frontiers in Immunology; Año: 2017 vol. 8

NOCERA, DAVID ANDRÉS; ROSELLI, EMILIANO; ARAYA, PAULA; NUÑEZ, NICOLÁS GONZALO; LIENENKLAUS, STEFAN; JABLONSKA, JADWIGA; WEISS, SIEGFRIED; GATTI, GERARDO; BRINKMANN, MELANIE M.; KRÖGER, ANDREA; MORÓN, GABRIEL; MACCIONI, MARIANA

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration

JOURNAL OF IMMUNOLOGY; Año: 2016 vol. 196 p. 2860 - 2869

PÉROL, LOUIS; LINDNER, JOHN M.; CAUDANA, PAMELA; NUNEZ, NICOLAS GONZALO; BAEYENS, AUDREY; VALLE, ANDREA; SEDLIK, CHRISTINE; LOIRAT, DELPHINE; BOYER, OLIVIER; CRÉANGE, ALAIN; COHEN, JOSÉ LAURENT; ROGNER, UTE CHRISTINE; YAMANOUCHI, JUN; MARCHANT, MARTINE; LEBER, XAVIER CHARLES; SCHARENBERG, MEIKE; GAGNERAULT, MARIE-CLAUDE; MALLONE, ROBERTO; BATTAGLIA, MANUELA; SANTAMARIA, PERE; HARTEMANN, AGNÈS; TRAGGIAI, ELISABETTA; PIAGGIO, ELIANE

Loss of immune tolerance to IL-2 in type 1 diabetes

NATURE COMMUNICATIONS; Año: 2016 vol. 7

ZACCA, ESTEFANÍA R.; CRESPO, MARÍA I.; ACLAND, RACHEL P.; ROSELLI, EMILIANO; NÚÑEZ, NICOLÁS G.; MACCIONI, MARIANA; MALETTO, BELKYS A.; PISTORESI-PALENCIA, MARÍA C.; MORÓN, GABRIEL

Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand

PLOS ONE; Año: 2015 vol. 10

TRUCCO, LUCAS DANIEL; ANDREOLI, VERÓNICA; NÚÑEZ, NICOLÁS GONZALO; MACCIONI, MARIANA; BOCCO, JOSÉ LUIS

Krüppel-like factor 6 interferes with cellular transformation induced by the H- ras oncogene

FASEB JOURNAL; Año: 2014 vol. 28 p. 5262 - 5276

CRESPO, M. I.; ZACCA, E. R.; NUNEZ, N. G.; RANOCCHIA, R. P.; MACCIONI, M.; MALETTO, B. A.; PISTORESI-PALENCIA, M. C.; MORON, G.

TLR7 Triggering with Polyuridylic Acid Promotes Cross-Presentation in CD8 + Conventional Dendritic Cells by Enhancing Antigen Preservation and MHC Class I Antigen Permanence on the Dendritic Cell Surface

JOURNAL OF IMMUNOLOGY; Año: 2013 vol. 190 p. 948 - 960

GATTI, GERARDO; NUÑEZ, NICOLÁS GONZALO; NOCERA, DAVID ANDRÉS; DEJAGER, LIEN; LIBERT, CLAUDE; GIRAUDO, CONSTANCIO; MACCIONI, MARIANA

Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-β production capable of improving dendritic cell function

EUROPEAN JOURNAL OF IMMUNOLOGY; Año: 2013 vol. 43 p. 1849 - 1861

NÚÑEZ NG, ANDREANI V, CRESPO MI, NOCERA DA, BRESER ML, MORÓN G, DEJAGER L, LIBERT C, RIVERO V, MACCIONI M.

IFNβ Produced by TLR4-Activated Tumor Cells Is Involved in Improving the Antitumoral Immune Response.

CANCER RESEARCH; Año: 2012 p. 592 - 603

CARRANZA F, FALCÓN C, NUÑEZ N, KNUBEL C, CORREA S, BIANCO S, MACCIONI M, FRETES R, TRIQUELL F, MOTRÁN C AND CERVI L.

Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells

PLOS ONE; Lugar: San Francisco; Año: 2012 p. 1 - 2

MACKERN OBERTI JP, BRESER ML, NUÑEZ N, MACCIONI M, RODRÍGUEZ N, WANTIA N, ERTL T, MIETHKE T, RIVERO VE.

Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells.

REPRODUCTION; Año: 2011 p. 427 - 437

KOWALJOW V; MARCOWYCZ A; ANSSEAU E; CONDE CB; SAUVAGE S; MATTÉOTTI C; ARIAS C; CORONA ED; NUÑEZ NG; LEO O; WATTIEZ R; FIGLEWICZ D; LAOUDJ-CHENIVESSE D; BELAYEW A; COPPÉE F; ROSA AL

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein

NEUROMUSCULAR DISORDERS; Año: 2007 vol. 17 p. 611 - 623