INVESTIGADORES
BERGUER Paula Mercedes
artículos
Título:
Characterization of two infectious mouse mammary tumour viruses: superantigenicity and tumorigenicity.
Autor/es:
BUGGIANO V, GOLDMAN A, NEPOMNASCHY I, BEKINSCHTEIN P, BERGUER P, LOMBARDI G, DEROCHE A, FRANCISCO MV, PIAZZON I.
Revista:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Editorial:
Blackwell Scientific Publications
Referencias:
Lugar: Oxford; Año: 1999 vol. 49 p. 269 - 277
ISSN:
0300-9475
Resumen:
Mouse mammary tumour virus (MMTV) is a type B retrovirus that causes
mammary tumours in susceptible mice. MMTV encodes a superantigen (SAg)
that has the property of stimulating T-cell populations expressing a
particular variable region of the T-cell receptor (TCR) beta chain
(Vbeta) and needs to be presented in the context of major
histocompatibility complex (MHC) class II molecules. Previously, we
described two exogenous MMTV, MMTV BALB14, which encodes a superantigen
that induces the deletion of Vbeta14+ Tcells, and MMTV BALB2, which
encodes a SAg that induces the deletion of Vbeta2+ Tcells. We now
describe their biological activity: the deletions involve both CD4+ and
CD8+ populations, are progressive and can be detected in blood, lymph
nodes and spleen. Such deletions reflect, at least in part, those
occurring during intrathymic development. Both BALB2 and BALB14 viral
variants are capable of inducing a strong increase of Vbeta-specific T
cells in BALB/c mice (I-A+, I-E+). However, when injected into the
footpad, their initial stimulatory capacity differs in that the
presence of MHC I-E molecules is essential only for the stimulation of
Vbeta2+ T cells. Both viral variants are able to induce deletion even
in the absence of the I-E molecule in which case, however, deletion
appears later and is less pronounced. Both exogenous MMTVs induce, at
the end of a year, 30-35% of pregnancy-dependent mammary
adenocarcinomas.