CIVETAN 23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005?2019.
Autor/es:
GOLPARIAN D; MAGUNS U; SPARO M AND OTHERS ; POKLEPOVICH T; TUDURI E; GALARZA P; GIANECINI R; CUENCA N; CAMPUS J
Revista:
EMERGING INFECTIOUS DISEASES (ONLINE)
Editorial:
www.cdc.gov/eid
Referencias:
Lugar: atlanta; Año: 2021 vol. 27 p. 2369 - 2378
ISSN:
1080-6059
Resumen:
Azithromycin-nonsusceptible Neisseria gonorrhoeaestrains are an emerging global public health threat. During2015?2018, the prevalence of azithromycin-nonsusceptiblegonococcal infection increased signifi cantly inArgentina. To investigate the genomic epidemiology andresistance mechanisms of these strains, we sequenced96 nonsusceptible isolates collected in Argentina during2005?2019. Phylogenomic analysis revealed 2 mainclades, which were characterized by a limited geographicdistribution, circulating during January 2015?November2019. These clades included the internationally spreadingmultilocus sequence types (STs) 1580 and 9363. TheST1580 isolates, which had MICs of 2?4 μg/mL, hadmutations in the 23S rRNA. The ST9363 isolates, whichhad MICs of 2?4 or >256 μg/mL, had mutations in the23S rRNA, a mosaic mtr locus, or both. Identifying thegeographic dissemination and characteristics of thesepredominant clones will guide public health policies tocontrol the spread of azithromycin-nonsusceptible N.gonorrhoeae in Argentina.
