CEQUINOR 05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol on 2D and 3D human osteosarcoma cancer cells
Autor/es:
BARAN, ENRIQUE J; QUISPE, PATRICIA; LEON, IGNACIO; BALSA, LUCIA M; LAVECCHIA, MARTIN
Revista:
METALLOMICS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2020 vol. 12 p. 1931 - 1940
ISSN:
1756-5901
Resumen:
The study of novel mechanisms of action of vanadium compoundsis critical to elucidating the role and importance of these kinds ofcompounds as antitumor and antimetastatic agents. This work dealswith in silico and in vitro studies of one clioquinol oxidovanadium(IV)complex [VO(clioquinol)2], VO(CQ)2, and its regulation of FAK. Inparticular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.
