Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose

ROSSI, ANDRES H.; OJEDA, DIEGO S.; VARESE, AUGUSTO; SANCHEZ, LAUTARO; GONZALEZ LOPEZ LEDESMA, MARIA M.; MAZZITELLI, IGNACIO; JULIÁ, ANABEL ALVAREZ; ROUCO, SANTIAGO OVIEDO; PALLARÉS, HORACIO M.; COSTA NAVARRO, GUADALUPE S.; RASETTO, NATALI; GARCIA, CORINA I.; WENKER, SHIRLEY D.; RAMIS, LILA Y.; BIALER, MAGALÍ G.; JOSE DE LEONE, MARIA; HERNANDO, C. ESTEBAN; SOSA, SANTIAGO; BIANCHIMANO, LUCIANA; RIOS, ANTONELLA; TREFFINGER CIENFUEGOS, MARIA SOLEDAD; CARAMELO, JULIO J.; LONGUEIRA, YESICA; LAUFER, NATALIA; ALVAREZ, DIEGO; CARRADORI, JORGE; PEDROZZA, DARIANA; RIMA, ALEJANDRA; ECHEGOYEN, CECILIA; ERCOLE, REGINA; GELPI, PAULA; MARCHETTI, SUSANA; ZUBIETA, MARTÍN; DOCENA, GUILLERMO; KREPLAK, NICOLAS; YANOVSKY, MARCELO; GEFFNER, JORGE; PIFANO, MARINA; GAMARNIK, ANDREA V.

Cell Reports Medicine

Elsevier

Lugar: Amsterdam; Año: 2021

2666-3791

Massive vaccination offers great promise for halting the global COVID-19 pandemic. However,limited supply and uneven vaccine distribution create an urgent need to optimize vaccinationstrategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination ofhealthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity afterone and two doses in a cohort of naïve or previously infected volunteers. By 21 days afterreceiving the first dose of vaccine, 94% of naïve participants develop spike-specific IgGantibodies. A single Sputnik V dose elicits higher antibody levels and virus neutralizing capacityin previously infected individuals than in naïve ones receiving the full two-dose schedule. Thehigh seroconversion rate after a single dose in naïve participants suggests a benefit of delayingsecond dose administration to increase the number of people vaccinated. The data presentedprovide information for guiding public health decisions in light of the current global healthemergency