Cancer-associated fibroblasts in breast tumor microenvironment.

GIORELLO MB.; BORZONE FR.; LABOVSKY V.; PICCIONI FV.; CHASSEING NA.

J Mammary Gland Biol Neoplasia.

Springer

Año: 2021 vol. 26 p. 135 - 155

Epub 2021 Jan 4. Years of investigation have shed light on a theory in which breast tumor epithelial cells are under the effect of the stromal microenvironment. This review aims to discuss recent findings concerning the phenotypic and functional characteristics of cancer associated fibroblasts (CAFs) and their involvement in tumor evolution, as well as their potential implications for anti-cancer therapy. In this manuscript, we reviewed that CAFs play a fundamental role in initiation, growth, invasion, and metastasis of breast cancer, and also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of this disease.